• Publications
  • Influence
Whole-Genome Patterns of Common DNA Variation in Three Human Populations
Individual differences in DNA sequence are the genetic basis of human variability. We have characterized whole-genome patterns of common human DNA variation by genotyping 1,586,383 single-nucleotideExpand
  • 1,186
  • 94
  • PDF
Reachability and distance queries via 2-hop labels
TLDR
We propose a new data structure for representing all distances in a graph that is based on 2-hop covers of the shortest paths, or of all paths, in the graph. Expand
  • 539
  • 76
  • PDF
Estimating local ancestry in admixed populations.
Large-scale genotyping of SNPs has shown a great promise in identifying markers that could be linked to diseases. One of the major obstacles involved in performing these studies is that theExpand
  • 305
  • 33
  • PDF
Polylogarithmic inapproximability
TLDR
We provide the first hardness result of a polylogarithmic approximation ratio for a natural NP-hard optimization problem. Expand
  • 237
  • 30
Fast and accurate inference of local ancestry in Latino populations
TLDR
We introduce methods for local ancestry inference which leverage the structure of linkage disequilibrium in the ancestral population (LAMP-LD), and incorporate the constraint of Mendelian segregation when inferring local ancestry in nuclear family trios ( LAMP-HAP). Expand
  • 184
  • 25
  • PDF
Identifying Personal Genomes by Surname Inference
TLDR
We show that surnames can be recovered from personal genomes by profiling short tandem repeats on the Y chromosome (Y-STRs) and querying recreational genetic genealogy databases. Expand
  • 859
  • 23
  • PDF
Improved approximation algorithms for the vertex cover problem in graphs and hypergraphs
  • E. Halperin
  • Mathematics, Computer Science
  • SODA '00
  • 1 February 2000
TLDR
We obtain improved algorithms for finding small vertex covers in bounded degree graphs and hypergraphs. Expand
  • 247
  • 23
A comparison of phasing algorithms for trios and unrelated individuals.
Knowledge of haplotype phase is valuable for many analysis methods in the study of disease, population, and evolutionary genetics. Considerable research effort has been devoted to the development ofExpand
  • 326
  • 22
  • PDF
Inference of locus-specific ancestry in closely related populations
TLDR
A characterization of the genetic variation of recently admixed populations may reveal historical population events, and is useful for the detection of single nucleotide polymorphisms (SNPs). Expand
  • 126
  • 20
  • PDF
Haplotype reconstruction from genotype data using Imperfect Phylogeny
TLDR
We present results for a highly accurate method for haplotype resolution from genotype data that shows that SNPs are organized in highly correlated blocks. Expand
  • 243
  • 19
  • PDF
...
1
2
3
4
5
...