Naloxone benzoylhydrazone (NalBzoH) analgesia.
- D. Paul, J. Levison, D. Howard, C. Pick, E. Hahn, G. Pasternak
- BiologyJournal of Pharmacology and Experimental…
- 1 November 1990
Observations confirm the opioid nature of NalBzoH analgesia and imply a supraspinal mechanism of action and antagonizes mu, delta and kappa 1 actions while retaining its ability to elicit analgesia through a novel and distinct suPRaspinal kappa 3 system.
Irreversible opiate agonists and antagonists: the 14- hydroxydihydromorphinone azines
- E. Hahn, M. Carroll-Buatti, G. Pasternak
- Chemistry, BiologyJournal of Neuroscience
- 1 May 1982
Investigation into the molecular actions of the 14- hydroxydihydromorphinone hydrazones has suggested that their irreversible actions can be explained by the formation of their azines, which irreversibly block opiate binding in vitro 20- to 40-fold more potently than their corresponding hydrozones.
Narcotic antagonists. 4. Carbon-6 derivatives of N-substituted noroxymorphones as narcotic antagonists.
- R. Heilman, E. Hahn, J. Fishman
- ChemistryJournal of Medicinal Chemistry
- 1 March 1975
The majority of the new narcotic antagonists exhibited oral potencies considerably superior to the parent compounds, with 6-methylene derivatives IIa and IIb showing the most impressive increases.
SPONTANEOUSLY HYPERTENSIVE RATS: DEPENDENCE ON AGE
- E. Hahn
- Biology, Chemistry
The results suggest that higher levels of sodium chloride and longer exposure to the diet may be required to observe the salt sensltivlty produced by 100 mN salt in the in vitro radioreceptor assay.
Brain opiate receptor concentrations are increased in adult spontaneously hypertensive rats.
- C. Martucci, E. Hahn
- BiologyEndocrine Research Communications
The increase in opiate receptor content of SHR rats coincides with the appearance of elevated blood pressure in these animals, and supports a concept in which an interaction between the endorphins and the endocrine system may be involved in the mechanisms controlling hypertension.
NALOXONE, A SPECIFIC OPIOID ANTAGONIST, REVERSES CHRONIC IDIOPATHIC CONSTIPATION
- M. Kreek, E. Hahn, R. Schaefer, J. Fishman
- Medicine, BiologyThe Lancet
- 5 February 1983
N-demethylation of morphine in rat brain is localised in sites with high opiate receptor content
- J. Fishman, E. Hahn, B. Norton
- Biology, ChemistryNature
- 6 May 1976
This study was initiated to locate the reaction at specific sites of N-demethylation of morphine by using a new, highly sensitive assay and found that an increase in the ratio of 3H to 14C in a specific tissue would serve to indicate the presence, and also the extent, of any in situ N- Demethylation.
Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone.
- M. Gistrak, D. Paul, E. Hahn, G. Pasternak
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 November 1989
Low doses of NalBzoH also partially reversed the inhibition of gastrointestinal transit in mice produced by morphine, antagonized completely morphine lethality and precipitated withdrawal in morphine-dependent mice, confirming its antagonist activity in mu receptors.
Receptor binding of [3H]naloxone benzoylhydrazone: a reversible kappa and slowly dissociable mu opiate.
- M. Price, M. Gistrak, Y. Itzhak, E. Hahn, G. Pasternak
- Biology, ChemistryMolecular Pharmacology
Competition studies indicated that the reversible binding corresponded to neither mu nor delta binding and may represent a novel subtype of kappa receptor and raised the possibility that the slow rate of dissociation was related to interactions with a guanine nucleotide-binding protein.
Irreversible opiate agonists and antagonists. II. Evidence against a bivalent mechanism of action for opiate azines and diacylhydrazones.
- E. Hahn, S. Nishimura, R. Goodman, G. Pasternak
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 December 1985
A series of opiate azines, including naloxonazine, naltrexonazine and oxymorphonazine produce both a wash-resistant inhibition of 3H-opioid binding and prolonged actions in vivo and the ability of these compounds to produce wash- resistant inhibition of binding probably did not result from a bivalent attachment of the ligand to two binding sites at once.