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Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity
Combinatorial libraries of rearranged hypervariable VH and VL sequences from nonimmunized human donors contain antigen specificities, including anti-self reactivities, created by random pairing ofExpand
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Repetitive DNA sequences in Drosophila
The satellite DNAs of Drosophila melanogaster and D. virilis have been examined by isopycnic centrifugation, thermal denaturation, and in situ molecular hybridization. The satellites melt over aExpand
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Sequences responsible for transcription termination on a gene segment in Saccharomyces cerevisiae.
We have mapped a signal sequence for mRNA 3'-end formation in Saccharomyces cerevisiae by using a Drosophila melanogaster DNA segment that complements a yeast adenine-8 mutation. That the 3' end ofExpand
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AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes
Affinity of integrin lymphocyte function-associated antigen 1 (LFA-1) is enhanced by conformational changes from the low-affinity closed form to the high-affinity (HA) open form of the ligand-bindingExpand
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A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo
Elevated expression of insulin-like growth factor-II (IGF-II) is frequently observed in a variety of human malignancies, including breast, colon, and liver cancer. As IGF-II can deliver a mitogenicExpand
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Identification and characterization of a human monoclonal antagonistic antibody AL‐57 that preferentially binds the high‐affinity form of lymphocyte function‐associated antigen‐1
LFA‐1 (αLβ2) mediates cell‐cell and cell‐extracellular matrix adhesions essential for immune and inflammatory responses. One critical mechanism regulating LFA‐1 activity is the conformational changeExpand
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Development of Mammalian Serum Albumin Affinity Purification Media by Peptide Phage Display
Several phage isolates that bind specifically to human serum albumin (HSA) were isolated from disulfide‐constrained cyclic peptide phage‐display libraries. The majority of corresponding syntheticExpand
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Transcription terminates in yeast distal to a control sequence
We have investigated transcription termination on a segment of Drosophila DNA that complements a yeast adenine-8 mutation. Poly(A)+ RNA transcribed from this segment in yeast terminates at multipleExpand
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The satellite DNAs of Drosophila virilis.
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Characterization and mapping to human chromosome 8q24.3 of Ly-6-related gene 9804 encoding an apparent homologue of mouse TSA-1.
The 9804 gene, which encodes a human Ly-6 protein most similar to mouse differentiation Ag TSA-1/Sca-2, has also been called RIG-E. Like mouse TSA-1, it has a broad tissue distribution with variedExpand
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