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Circadian variation in the mitotic rate of the rat corneal epithelium
TLDR
A mathematical model showing isomorphism with the renewal of the corneal epithelium is developed, which indicates that both tissues are submitted to the same regulatory mechanisms.
Cell renewal of the rat corneal epithelium
TLDR
The mitotic rate is almost equal all over the cornea, with no definite reduction in the central areas, and there is no area of significantly high proliferation rate, either in the limbal area or in the adjacent conjunctiva.
Cell kinetics during healing of corneal epithelial wounds
TLDR
It was demonstrated that the conjunctiva itself plays a role in the healing of a central corneal epithelium wound, and no support was found for the theory that the limbal area serves as a generative organ for the cornea.
Circadian variation in cell proliferation and maturation
TLDR
This interaction between the circadian proliferative factor and the negative feedback factor for regulation of proliferation with its accompanying stimulatory effect on maturation, may represent a general mechanism in the regulation of cell proliferation in any tissue.
EARLY CELL KINETIC EFECTS OF A SINGLE DOSE OF NARROW‐BANDED ULTRAVIOLET B IRRADIATION ON THE RAT CORNEAL EPITHELUM
TLDR
The right eyes of 40 rats were exposed to a signal erythemogenic dose fo ultraviolet B irradiation (UVB) at 297nm and the block in cell proliferation was followed by increased proliferation.
Migration of cells in the rat corneal epithelium
TLDR
The slow centripetal migration of epithelial cells and the exchange of centrally located cells, as indicated by clinical findings and experimental studies, can only be explained by migration of basal cells.
Circadian variations in the DNA synthesis of the rat corneal epithelium
TLDR
The LI is thus not a reliable indicator of cell proliferation in the corneal epithelium, due both to the heterogeneity of the cell proliferation, and in particular due to the lack of labelling of the centrally located DNA-synthesizing cells.
The influence of technical procedures on cell countings in the rat corneal epithelium: a statistical analysis.
TLDR
A large proportion of the variation in the cell counts must be a result of the technical procedures, and is thus not an intrinsic property of the corneal epithelium.
Two cell kinetic methods studied on the rat corneal epithelium
TLDR
Topical application of small doses of both Colcemid and [3H]TdR makes interesting in vivo experiments on larger animals and even on human beings possible, due to the extreme regularity of the corneal epithelium.
Isolation and culture of basal cells of the human corneal epithelium
TLDR
It is demonstrated that this population of viable basal cells of the human corneal epithelium can be maintained in culture with a maintained epithelial phenotype, DNA‐synthesis, migratory and mitotic activity.
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