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The gastric cytoprotective effect of several sesquiterpene lactones.
TLDR
The results obtained from the different sesquiterpene lactones studied suggest that the presence of the alpha-methylene-gamma-lactone moiety is, in principle, a requirement for the observed antiulcerogenic activity. Expand
Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones.
TLDR
The biological evaluation of reduced analogues and the simulation of the molecular interactions between these compounds and an endogenous cysteine residue suggest that the presence of a non sterically hindered Michael acceptor seems to be an essential structural requirement for the cytoprotective activity in this family of compounds. Expand
Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana.
TLDR
It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines. Expand
Acute and chronic antiinflammatory effects of plant flavonoids.
TLDR
It is concluded that several of the isolated flavonoids tested here showed antiinflammatory effects, depending on the experimental model used, and Flavonoids significantly inhibited the maximum edema response in the acute test. Expand
THE SESQUITERPENE LACTONE DEHYDROLEUCODINE (DhL) AFFECTS THE GROWTH OF CULTURED EPIMASTIGOTES OF TRYPANOSOMA CRUZI
TLDR
The inhibitory effect of a sesquiterpene lactone dehydroleucodine (DhL) on the growth of Trypanosoma cruzi in culture was reported and Morphological changes induced by DhL were also observed in the parasites. Expand
Enhancement of tessaric acid production in Tessaria absinthioides cell suspension cultures
TLDR
The total production of the sesquiterpene tessaric acid by cell cultures of Tessaria absinthioides at day 25 of the culture period reached 0.086 mg g−1 DW, with intracellular accumulation accounting for 0.059’sulfoxide-induced permeabilization of the cells. Expand
Sesquiterpenes and flavonoids from Tessaria species
TLDR
The aerial parts of T. integrifolia and T. fastigiata afforded three new and three previously reported eudesname derivatives. Expand
Anti-inflammatory activity of acetophenones from Ophryosporus axilliflorus.
Seven acetophenone derivatives were isolated from the aerial parts of Ophryosporus axilliflorus (Griseb.) Hieron. These compounds were subjected to the carrageenan-induced mouse paw edema test whereExpand
Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor.
Growth-inhibitory activities of selected natural benzofurans (4-9), trans-cinnamic acid derivatives (10-13), chromene compounds (14 and 16), and some semisynthetic derivatives were determined in lastExpand
Gastric cytoprotective activity of dehydroleucodine in rats. Role of nitric oxide.
TLDR
The findings suggest that NO is involved in the gastroprotection induced by DhL, and the gastric cytoprotective effect is antagonized by the nitric oxide synthase inhibitor, NG-nitro-L-arginine. Expand
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