• Publications
  • Influence
Chronology of behavioral symptoms and neuropathological sequela in R6/2 Huntington's disease transgenic mice
TLDR
The findings suggest that the R6/2 HD model exhibits a progressive HD‐like behavioral and neuropathological phenotype that more closely corresponds to human HD than previously believed, providing further assurance that theR6/ 2 mouse is an appropriate model for testing potential therapies for HD. Expand
Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance
TLDR
It is demonstrated that aging in a diurnal vertebrate, zebrafish (Danio rerio), is associated with major but selective circadian alterations, and the ability of melatonin to acutely promote sleep and entrain circadian rhythms of activity remains robust until at least 4-5 years of age, consistent with the preserved levels of mRNA expression for melatonin receptors. Expand
Three genes for mitochondrial proteins suppress null-mutations in both Afg3 and Rca1 when over-expressed
TLDR
Three genes were found that restored partial growth on non-fermentable carbon sources, all of which affect the biogenesis of respiratory competent mitochondria and suppressed a null mutation in a related gene, RCA1, as well as in the combination of afg3- and rca1-null. Expand
ATP synthase of yeast mitochondria. Isolation and disruption of the ATP epsilon gene.
TLDR
The nuclear gene encoding the subunit epsilon of the catalytic sector F1 of the yeast Saccharomyces cerevisiae ATP synthase was cloned and sequenced and a null mutant was constructed, which promoted a highly oligomycin-sensitive uncoupling of the mitochondrial respiration rate. Expand
Yeast sequencing reports. Sequence of the AFG3 gene encoding a new member of the FtsH/Yme1/Tma subfamily of the AAA‐protein family
A nuclear gene from Saccharomyces cerevisiae was cloned by genetic complementation of a temperature‐sensitive respiratory‐deficient mutant. DNA sequence analysis reveals that it encodes a proteinExpand
Isolation of the ATP synthase subunit 6 and sequence of the mitochondrial ATP6 gene of the yeast Candida parapsilosis.
TLDR
Comparison between protein and DNA sequences shows that the CUN codon family codes for a leucine in C. parapsilosis mitochondria as in Saccharomyces cerevisiae. Expand
Afg3p, a mitochondrial ATP‐dependent metalloprotease, is involved in degradation of mitochondrially‐encoded Cox1, Cox3, Cob, Su6, Su8 and Su9 subunits of the inner membrane complexes III, IV and V
TLDR
Surprisingly, this proteolytic activity of yeast AFG3 is not required for respiratory function and thus presumably also not essential for mitochondrial biogenesis. Expand
The second respiratory chain of Candida parapsilosis: a comprehensive study.
TLDR
The yeast C. parapsilosis develops a second electron transfer chain antimycin A-insensitive which allows the oxidation of cytoplasmic NAD(P)H resulting from glycolytic and hexose monophosphate pathways functioning through a route different from the NADH-coenzyme Q oxidoreductase described in S. cerevisiae. Expand
F-Spondin/spon1b Expression Patterns in Developing and Adult Zebrafish
TLDR
Patterning of the regenerating caudal fin following fin amputation in adult zebrafish was associated with F-spondin expression in the blastema, a proliferative region critical for tissue reconstitution. Expand
...
1
2
...