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Potential pitfalls of propofol target controlled infusion delivery related to its pharmacokinetics and pharmacodynamics.
Target controlled infusion (TCI) devices are increasingly used in clinical practice. These devices unquestionably aid optimization of drug dosage. However, it still remains to be determined if theyExpand
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Influence of Obesity and Type 2 Diabetes Mellitus on the Pharmacokinetics of Tramadol After Single Oral Dose Administration
Background and ObjectivesThe number of overweight, obese and diabetic patients is constantly increasing. Metabolic disorders may affect the pharmacokinetics of drugs, e.g., by altering the activityExpand
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The effect of bradykinin on the oxidative state of rats with acute hyperglycaemia.
Many clinical and experimental studies have established the beneficial effect of kinins in hypertension, heart failure and ischaemia-reperfusion syndrome, but little attention has been given to theExpand
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The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level.
It is claimed that application of botanical supplements or herbal medicinal products with synthetic drugs that are cytochrome P450 enzymes substrates may induce significant herb-drug interactions andExpand
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The PK/PD index (CMAX/MIC) for ciprofloxacin in patients with cystic fibrosis.
In order to evaluate the efficacy of an antibacterial therapy, three basic PK/PD indexes were defined: the ratio between the maximum drug concentration obtained after a single dose and minimumExpand
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The physical and chemical stability of cisplatin (Teva) in concentrate and diluted in sodium chloride 0.9%
Aim of the study The subject of study was the stability of cisplatin in concentrate in glass vials and diluted in polyethylene (PE) bags stored at 15–25°C for up to 30 days. Material and methodsExpand
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[Influence of standardized extract of Epilobium angustifolium on estrogen receptor alpha and beta expression in in vivo model].
OBJECTIVE Evaluation of the influence of the standardized extract from the herb of Epilobium angustifolium on ERalpha and ERbeta mRNA expression in rat ventral prostate tissue and free serumExpand
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The pharmacokinetics of dexmedetomidine during long-term infusion in critically ill pediatric patients. A Bayesian approach with informative priors
The purpose of this study was to assess the pharmacokinetics of dexmedetomidine in the ICU settings during the prolonged infusion and to compare it with the existing literature data using theExpand
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The influence of the time of day on midazolam pharmacokinetics and pharmacodynamics in rabbits.
BACKGROUND This study evaluates the time-of-day effect on midazolam and 1-OH midazolam pharmacokinetics, and on the sedative pharmacodynamic response in rabbits. Also, circadian fluctuations inExpand
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Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
Human cytochrome P450 1A 1 is one of the most important enzymes participating in human carcinogenesis because it metabolites several procarcinogens to active carcinogenic metabolites. AdditionallyExpand
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