• Publications
  • Influence
Lateral gene transfer and the nature of bacterial innovation
Unlike eukaryotes, which evolve principally through the modification of existing genetic information, bacteria have obtained a significant proportion of their genetic diversity through theExpand
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The pleiotropic two-component regulatory system PhoP-PhoQ.
  • E. Groisman
  • Biology, Medicine
  • Journal of bacteriology
  • 15 March 2001
PhoP-PhoQ is a two-component system that governs virulence, mediates the adaptation to Mg 21 -limiting environments, and regulates numerous cellular activities in several gram-negative species. ItExpand
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Identification of a pathogenicity island required for Salmonella survival in host cells.
We have identified a region unique to the Salmonella typhimurium chromosome that is essential for virulence in mice. This region harbors at least three genes: two (spiA and spiB) encode products thatExpand
  • 648
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  • Open Access
Role of Nonhost Environments in the Lifestyles of Salmonella and Escherichia coli
The gram-negative bacterial species Salmonella enterica and Escherichia coli are members of the family Enterobacteriaceae that spend a good part of their lives as residents of animal hosts. S.Expand
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Mg2+ as an Extracellular Signal: Environmental Regulation of Salmonella Virulence
Ions are not traditionally thought to act as first messengers in signal transduction cascades. However, while searching for genes regulated by the PhoP/PhoQ virulence regulatory system of SalmonellaExpand
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A Salmonella virulence protein that inhibits cellular trafficking
Salmonella enterica requires a type III secretion system, designated Spi/Ssa, to survive and proliferate within macrophages. The Spi/Ssa system is encoded within the SPI‐2 pathogenicity island andExpand
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  • Open Access
The Salmonella selC locus contains a pathogenicity island mediating intramacrophage survival
Pathogenicity islands are chromosomal clusters of horizontally acquired virulence genes that are often found at tRNA loci. The selC tRNA locus of Escherichia coli has served as the site ofExpand
  • 330
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  • Open Access
The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica.
The PmrA/PmrB regulatory system of Salmonella enterica controls the modification of lipid A with aminoarabinose and phosphoethanolamine. The aminoarabinose modification is required for resistance toExpand
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  • Open Access
A Signal Transduction System that Responds to Extracellular Iron
Iron is essential for all organisms but can be toxic in excess. Iron homeostasis is typically regulated by cytoplasmic iron binding proteins, but here we describe a signal transduction systemExpand
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Virulence and drug resistance roles of multidrug efflux systems of Salmonella enterica serovar Typhimurium
Drug efflux systems play a major role in resistance to a wide range of noxious compounds in several Gram negative species. Here, we report the drug resistance and virulence phenotypes of SalmonellaExpand
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