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Bacterial biofilms: a common cause of persistent infections.
TLDR
Improvements in understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
The involvement of cell-to-cell signals in the development of a bacterial biofilm.
TLDR
The involvement of an intercellular signal molecule in the development of Pseudomonas aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aerug inosaBiofilms are a persistent problem.
Identification, Timing, and Signal Specificity of Pseudomonas aeruginosa Quorum-Controlled Genes: a Transcriptome Analysis
TLDR
It is suggested that the level of the signal receptor, LasR, is a critical trigger for quorum-activated gene expression, and acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture.
Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators
TLDR
How the marine luminescent bacterium V. fischeri uses the LuxR and LuxI proteins for intercellular communication is reviewed and a newly discovered family of LuxRand LuxI homologs in diverse bacterial species is described.
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa.
TLDR
The demonstration that 2-heptyl-3-hydroxy-4-quinolone can function as an intercellular signal sheds light on the role of secondary metabolites and shows that P. aeruginosa cell-to-cell signaling is not restricted to acyl-homoserine lactones.
Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi
Different species of bacteria were tested for production of extracellular autoinducer-like activities that could stimulate the expression of the luminescence genes in Vibrio harveyi. Several species
Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.
TLDR
Recent studies have begun to integrate acyl-HSL quorum sensing into global regulatory networks and establish its role in developing and maintaining the structure of bacterial communities.
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.
TLDR
The elucidation of the PAI structure suggests therapeutic approaches toward control of P. aeruginosa infections and is shown to have chemical and biological properties identical to those of PAI purified from culture supernatant fluids.
Census and consensus in bacterial ecosystems: the LuxR-LuxI family of quorum-sensing transcriptional regulators.
TLDR
Genetic analyses of particular bacterial genes, operons, or regulons that are expressed preferentially at high cell densities have revealed a high degree of functional conservation, while also uncovering features that are unique to each.
A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.
TLDR
The role of factor 2 in virulence gene regulation remains to be determined, but this compound may affect the expression of lasR, which in turn activation of numerous virulence genes in the presence of sufficient PAI.
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