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A novel computational model of the human ventricular action potential and Ca transient.
We have developed a detailed mathematical model for Ca handling and ionic currents in the human ventricular myocyte. Our aims were to: (1) simulate basic excitation-contraction coupling phenomena;Expand
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Reactive Oxygen Species–Activated Ca/Calmodulin Kinase II&dgr; Is Required for Late INa Augmentation Leading to Cellular Na and Ca Overload
Rationale: In heart failure Ca/calmodulin kinase (CaMK)II expression and reactive oxygen species (ROS) are increased. Both ROS and CaMKII can increase late INa leading to intracellular NaExpand
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Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
Rationale: Understanding atrial fibrillation (AF) requires integrated understanding of ionic currents and Ca2+ transport in remodeled human atrium, but appropriate models are limited. Objective: ToExpand
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  • Open Access
Ca/Calmodulin Kinase II Differentially Modulates Potassium Currents
Background—Potassium currents contribute to action potential duration (APD) and arrhythmogenesis. In heart failure, Ca/calmodulin-dependent protein kinase II (CaMKII) is upregulated and can alter ionExpand
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  • Open Access
Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal.
BACKGROUND Although sudden death is one of the most frequent causes of death in haemodialysis (HD) patients, the problem of cardiac arrhythmias, the major cause of these outcomes, has been littleExpand
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  • Open Access
Ranolazine for Congenital and Acquired Late INa-Linked Arrhythmias: In Silico Pharmacological Screening
Rationale: The antianginal ranolazine blocks the human ether-a-go-go–related gene–based current IKr at therapeutic concentrations and causes QT interval prolongation. Thus, ranolazine isExpand
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Ion Channels in the Heart.
Optimal cardiac function depends on proper timing of excitation and contraction in various regions of the heart, as well as on appropriate heart rate. This is accomplished via specialized electricalExpand
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  • Open Access
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials.
Ca-calmodulin-dependent protein kinase II (CaMKII) was recently shown to alter Na(+) channel gating and recapitulate a human Na(+) channel genetic mutation that causes an unusual combinedExpand
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Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of IKr Inhibition on Ventricular Repolarization
Background— The reverse rate dependence (RRD) of actions of IKr-blocking drugs to increase the action potential duration (APD) and beat-to-beat variability of repolarization (BVR) of APD isExpand
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  • Open Access
β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets.
Sympathetic stimulation regulates cardiac excitation-contraction coupling in hearts but can also trigger ventricular arrhythmias caused by early afterdepolarizations (EADs) in pathologicalExpand
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