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Conformation and aggregation of melittin: dependence on pH and concentration.
Melittin, a 26-residue peptide from bee venom, is transformed from a largely random to a largely alpha-helical conformation at elevated pH. At 3 x 10(-5) M melittin, circular dichroism spectra show aExpand
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Poly ICL-CM dextran: an interferon inducer of reduced toxicity.
We have prepared soluble complexes of poly ICL-CM dextran that are as effective interferon IFN inducers, in mice and in rhesus monkeys, as poly ICLC. Toxicity testing was carried out in mice and,Expand
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Interactions of poly(N epsilon, N epsilon, N epsilon-trimethyllysine) and poly(N delta, N delta, N delta-trimethylornithine) with polynucleotides: salt dissociation and thermal denaturation.
The interaction of poly(N epsilon, N epsilon, N epsilon-trimethyl-L-lysine) ([Lys(Me3)]n) and poly(N delta, N delta, N delta-trimethyl-L-ornithine) ([Orn(Me3)]n) with polynucleotides was studied byExpand
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Human serum digests poly(rI) X poly(rC) differently from other mammalian sera.
Using a new spectrophotometric assay, we found that human serum digests predominately (rC)n of (rI)n X (rC)n, in agreement with results of Nordlund et al. (Proc. Soc. Exp. Biol. Med., 1970, 133,Expand
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Interactions of poly (N epsilon , N epsilon , N epsilon ,-trimethyllysine) and poly(lysine) with polynucleotides: circular dichroism and A-T sequence selectivity.
Complexes of (Lys) and [Lys(Me3)]n with natural and synthetic DNAs have been studied by CD as a function of ionic strength. In dilute EDTA, (Lys)n and [Lys(Me3)]n produce the same distortions to theExpand
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Alkylated poly(amino acids). I. Conformational properties of poly(Nε‐trimethyl‐L‐lysine) and poly(Nδ‐trimethyl‐L‐ornithine)
Poly(Nε‐trimethyl‐L‐lysine), [Lys(Me3)]n, and poly(Nδ‐trimethyl‐L‐ornithine), [Orn(Me3)]n, in sodium dodecylsulfate do not assume the β‐structure or α‐helix, respectively, of their parent polymers.Expand
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Methylated poly(L-lysine): conformational effects and interactions with polynucleotides.
Methylated lysine, arginine and histidine residues are found in a number of proteins (for example, histones, non-histone chromosomal proteins, ribosomal proteins, calmodulin, cytochrome C, etc.). WeExpand
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Poly ICLC induces anti-IC antibodies in mice and rabbits.
Poly ICLC is an interferon (IFN) inducer and antiviral, antitumor, radioprotective, and immunoregulatory agent. We show that administration of poly ICLC to mice and rabbits also results in theExpand
Preparation and assay of poly ICL-CM dextran, an interferon inducer of reduced toxicity.
Publisher Summary This chapter presents preparation and assay method of poly ICL-CM dextran, an interferon inducer of reduced toxicity. This complex also has activity as an immunological adjuvant,Expand
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Purification of carboxymethylcellulose decreases toxicity of poly ICLC in mice.
The interferon inducer poly ICLC has toxic side effects; the carboxymethylcellulose (CMC) component is a possible source of this toxicity. We have purified CMC by ethanol extraction, and found thatExpand