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Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia.
Wild waterfowl, including ducks, are natural hosts of influenza A viruses. These viruses rarely caused disease in ducks until 2002, when some H5N1 strains became highly pathogenic. Here we show thatExpand
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Are Ducks Contributing to the Endemicity of Highly Pathogenic H5N1 Influenza Virus in Asia?
ABSTRACT Wild waterfowl are the natural reservoir of all influenza A viruses, and these viruses are usually nonpathogenic in these birds. However, since late 2002, H5N1 outbreaks in Asia haveExpand
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The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04
H5N1 influenza viruses transmitted from poultry to humans in Asia cause high mortality and pose a pandemic threat. Viral genes important for cell tropism and replication efficiency must be identifiedExpand
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H5N1 influenza--continuing evolution and spread.
We don't know whether the next influenza pandemic will be caused by the H5N1 avian influenza virus. But Drs. Robert Webster and Elena Govorkova write that given the number of cases of H5N1 influenzaExpand
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Lethality to Ferrets of H5N1 Influenza Viruses Isolated from Humans and Poultry in 2004
ABSTRACT The 2004 outbreaks of H5N1 influenza viruses in Vietnam and Thailand were highly lethal to humans and to poultry; therefore, newly emerging avian influenza A viruses pose a continued threat,Expand
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Characterization of H5N1 Influenza Viruses That Continue To Circulate in Geese in Southeastern China
ABSTRACT The H5N1 influenza virus, which killed humans and poultry in 1997, was a reassortant that possibly arose in one type of domestic poultry present in the live-poultry markets of Hong Kong.Expand
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Influenza: Emergence and Control
The natural reservoirs of influenza A viruses are the aquatic birds of the world (91), in which the viruses appear to be in evolutionary stasis—they are in equilibrium with their natural host andExpand
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Importance of Neuraminidase Active-Site Residues to the Neuraminidase Inhibitor Resistance of Influenza Viruses
ABSTRACT Neuraminidase inhibitors (NAIs) are antivirals designed to target conserved residues at the neuraminidase (NA) enzyme active site in influenza A and B viruses. The conserved residues thatExpand
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Epitope Mapping of the Hemagglutinin Molecule of a Highly Pathogenic H5N1 Influenza Virus by Using Monoclonal Antibodies
ABSTRACT We mapped the hemagglutinin (HA) antigenic epitopes of a highly pathogenic H5N1 influenza virus on the three-dimensional HA structure by characterizing escape mutants of a recombinant virusExpand
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T-705 (Favipiravir) Induces Lethal Mutagenesis in Influenza A H1N1 Viruses In Vitro
ABSTRACT Several novel anti-influenza compounds are in various phases of clinical development. One of these, T-705 (favipiravir), has a mechanism of action that is not fully understood but isExpand
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