Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin.
- E. Fiebiger, C. Hirsch, J. Vyas, E. Gordon, H. Ploegh, D. Tortorella
- BiologyMolecular Biology of the Cell
- 1 April 2004
The use of eeyarestatin I allows the definition of a new intermediate in dislocation, and both compounds stabilize these dislocation substrates in the ER membrane, without preventing proteasomal turnover of cytosolic substrates.
Inhibition of L-selectin-mediated Leukocyte Rolling by Synthetic Glycoprotein Mimics*
- W. J. Sanders, E. Gordon, O. Dwir, P. Beck, R. Alon, L. Kiessling
- Biology, ChemistryJournal of Biological Chemistry
- 26 February 1999
The data indicate that multivalent ligands are far more effective inhibitors of L-selectin-mediated rolling than their monovalent counterparts and that the inhibitory activities are dependent on the specific sulfation pattern of the recognition epitope.
Synthetic glycoprotein mimics inhibit L-selectin-mediated rolling and promote L-selectin shedding.
- P. Mowery, Zhi-Qiang Yang, L. Kiessling
- Biology, ChemistryChemistry and Biology
- 1 May 2004
Small-molecule screening: it takes a village...
- E. Gordon
- MedicineACS Chemical Biology
- 23 January 2007
Intraductal therapy of ductal carcinoma in situ: a presurgery study.
- M. Mahoney, E. Gordon, J. Rao, Yusheng Jin, N. Hylton, S. Love
- MedicineClinical Breast Cancer
- 1 August 2013
Synthetic ligands point to cell surface strategies
- E. Gordon, W. J. Sanders, L. Kiessling
- Biology, ChemistryNature
- 5 March 1998
A new class of multivalent ligands, ‘neoglycopolymers’, are created, designed to promote the proteolytic cleavage of a cell adhesion molecule involved in the inflammatory response, L-selectin, which suggest new strategies to generate anti-inflammatory agents and regulate the cell surface.
Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions.
- E. Gordon, J. Gestwicki, L. E. Strong, L. Kiessling
- Biology, ChemistryChemistry and Biology
- 2000
Transforming the cell surface through proteolysis.
- L. Kiessling, E. Gordon
- BiologyChemistry and Biology
- 1 March 1998
Glycoprotein-inspired materials promote the proteolytic release of cell surface L-selectin.
- E. Gordon, L. E. Strong, L. Kiessling
- BiologyBioorganic & Medicinal Chemistry
- 1 August 1998
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