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Clinicopathological study of nephrotic syndrome in childhood.
It seems that the likelihood of an individual responding to cytotoxic drugs can be predicted from his initial steroid response alone, and a favourable outcome despite resistance to conventional therapy is found. Expand
Quartan malarial nephrotic syndrome. Collaborative clinicopathological study in Nigerian children.
The findings in this study are consistent with the hypothesis that Q.M.N.N is an immunologically mediated disorder initiated by quartan malarial infection and which, once established, pursues a progressive course. Expand
Noninvasive discrimination of brachial plexus involvement in upper limb pain.
The ability of Elvey's "brachial plexus tension test" to identify pain referred from the cervical region was investigated in 50 patients with unilateral shoulder and upper arm pain, suggesting that the test is able to discriminate referred and local sources of upper limb pain. Expand
Bacteria, bile salts, and intestinal monosaccharide malabsorption
It is suggested that this defect is caused by the presence of high levels of deconjugated bile salts produced by an abnormal anaerobic bacterial flora in the small intestine, which is a further consequence of bacterial contamination of the upper gut. Expand
Charge selectivity in kidney ultrafiltration.
The inhibitory action of oxygen radical scavengers on proteinuria and glomerular heparan sulphate loss in the isolated perfused kidney.
- M. Tay, W. Comper, P. Vassiliou, E. Glasgow, M. Baker, L. Pratt
- Chemistry, Medicine
- Biochemistry international
Results suggest that reactive oxygen metabolites may be involved in damage to renal capillaries, specifically to heparan sulfate proteoglycan, which leads to proteinuria as a result of partial ischemia produced during perfusion. Expand
Tissue culture of isolated glomeruli in experimental crescentic glomerulonephritis
- S. Holdsworth, N. Thomson, E. Glasgow, J. Dowling, R. Atkins
- Medicine, Biology
- The Journal of experimental medicine
- 1 January 1978
The predominance of the macrophage in cultures of glomeruli from both human and animal crescentic glomerulonephritis suggests that this is an important cell in the inflammatory reaction occurring in crescenti nephritis and may comprise a substantial proportion of the cells forming the crescent. Expand
Membranoproliferative Glomerulonephritis and Persistent Hypocomplementaemia
The clinical, laboratory, and histological findings of 50 patients with membranoproliferative glomerulonephritis are described, finding that all patients had substantial proteinuria, usually of moderately impaired selectivity, and all but one had haematuria in addition. Expand
Haemolytic-uraemic Syndrome Treated with Heparin
It is suggested that heparin therapy, by preventing further intrarenal thrombosis, allowed the normal fibrinolytic mechanisms to remove previously formed thrombi in children with the haemolytic-uraemic syndrome. Expand
Poststreptococcal glomerulonephritis in children: Clinicopathological correlations and long-term prognosis
The long-term outcome of PSGN in children is excellent, although 20% of subjects had urinary abnormalities, and the initial biopsy grade correlated significantly with heavy proteinuria but not with hypertension, haematuria or renal functional impairment. Expand