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Polyvalent dendrimer glucosamine conjugates prevent scar tissue formation
Dendrimers are hyperbranched macromolecules that can be chemically synthesized to have precise structural characteristics. We used anionic, polyamidoamine, generation 3.5 dendrimers to make novelExpand
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HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo.
The aim of this study was to compare in vitro and in vivo HPMA copolymer platinates with cisplatin in terms of platinum release, toxicity and antitumour activity. N-(2-hydroxypropyl)methacrylamideExpand
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Chitosan microcapsules as controlled release systems for insulin.
This study analyses the use of chitosan for the production of surface crosslinked microparticulate systems containing insulin. The microcapsules were prepared by an innovative technique based onExpand
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Synthesis, characterisation and antitumour activity of platinum(II) complexes of novel functionalised poly(amido amine)s
Polyamidoamine polymers were prepared by hydrogen-transfer polyaddition of 2-methylpiperazine to 2,2'-bis(acrylamido)acetic acid sodium salt to yield PAA-1, polyaddition of amino-β-cyclodextrin andExpand
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HPMA Copolymers Platinates Containing Dicarboxylato Ligands. Preparation, Characterisation and In Vitro and In Vivo Evaluation
N -(2-Hydroxypropyl)methacrylamide (HPMA) copolymer platinates were prepared from polymeric intermediates containing Gly-Phe-Leu-Gly side chains terminating in either malonate or aspartateExpand
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Indomethacin loaded chitosan microspheres. Correlation between the erosion process and release kinetics.
The preparation of chitosan microspheres covalently linked with citric acid and loaded with indomethacin is described. The release kinetics correlated with the concentration of chitosan in theExpand
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Chitosan‐Indomethacin Conjugates. Effect of Different Substituents on the Polysaccharide Molecule on Drug Release
The conjugation of indomethacin with chitosan partially substituted with the hydrophilic residues triethylene glycol glutarate and triethylene glycol choline ether glutarate is described.Expand
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Pharmaceutical and biological characterisation of a doxorubicin-polymer conjugate (PK1) entrapped in sorbitan monostearate Span 60 niosomes
A doxorubicin N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugate (PK1) designed for intracellular lysosomal cleavage following fluid phase pinocytic uptake is currently in early clinicalExpand
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A novel modification of poly(L-lysine) leading to a soluble cationic polymer with reduced toxicity and with potential as a transfection agent
Chemical modification of poly(L-lysine) by hydrogen transfer addition of N,N-dimethylacrylamide to the primary amino groups results in new water soluble derivatives with reduced cell toxicity whichExpand
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Release of ketoprofen from microspheres of poly (2-hydroxyethyl methacrylate) or poly (2-hydroxyethyl methacrylate)-co-β-methacryloyloxyethyl deoxycholate crosslinked with ethylene glycol
This study analyses the effect of deoxycholic acid covalently bound to the monomer on loading levels and release kinetics of ketoprofen from poly (2-hydroxyethyl methacrylate), ethylene glycolExpand
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