E. Getzoff

Publications379
h-index72
Citations20,608
Highly Influential Citations793
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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene (SOD1) occur in patients with the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). Complete screening…
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Structure of the fibre-forming protein pilin at 2.6 Å resolution
TLDR
The crystallographic structure of Neisseria gonorrhoeae pilin reveals an α–β roll fold with a striking 85 Å α-helical spine and an 0-linked disaccharide to stabilize interactions that allow sequence hypervariability, responsible for pilin's celebrated antigenic variation, within disulphide region β-strands and connections.
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The structural biochemistry of the superoxide dismutases.
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Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1
TLDR
Structures of pyrabactin resistance 1 (PYR1), a prototypical PYR/PYP1-like (PYL)/regulatory component of ABA receptor (RCAR) protein that functions in early ABA signaling are reported.
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Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions.
TLDR
An emerging PYR/RCAR-PP2C-SnRK2 model of ABA signal transduction provides researchers with a framework through which early ABA signaling can be understood, and allow novel questions about the hormone response pathway and possible applications in stress resistance engineering of plants to be addressed.
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Identification of a new cryptochrome class. Structure, function, and evolution.
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Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges
Donuts Dissociate In Arabidopsis, the UVR8 protein responds to ultraviolet-B (UV-B) light by dissociating into monomers, which are then available to interact with downstream factors that enact the…
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Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, the substrate L-arginine (L-Arg), or product analog thiocitrulline reveal…
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1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.
TLDR
The high-resolution structure of photoactive yellow protein supports a mechanism whereby electrostatic interactions create an active site poised for photon-induced rearrangements and efficient protein-mediated signal transduction.
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Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
TLDR
The atomic structure of the bleached signaling intermediate in the light cycle of PYP was determined by millisecond time-resolved, multiwavelength Laue crystallography and simultaneous optical spectroscopy to suggest a general framework for the interpretation of protein photocycles.
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