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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase.
Single-site mutants in the Cu,Zn superoxide dismutase (SOD) gene (SOD1) occur in patients with the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). Complete screening… Expand
Structure of the fibre-forming protein pilin at 2.6 Å resolution
- H. Parge, K. Forest, M. Hickey, D. Christensen, E. Getzoff, J. Tainer
- Biology, Medicine
- 2 November 1995
The crystallographic structure of Neisseria gonorrhoeae pilin, which assembles into the multi-functional pilus adhesion and virulence factor, reveals an α–β roll fold with a striking 85 Å α-helical… Expand
Structural Mechanism of Abscisic Acid Binding and Signaling by Dimeric PYR1
ABA Receptor Up Close Plants face a variety of environmental stresses, including drought, salinity, and cold. In the face of such stresses, the plant hormone abscisic acid (ABA) triggers adaptive… Expand
The structural biochemistry of the superoxide dismutases.
- J. Perry, D. Shin, E. Getzoff, J. Tainer
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 February 2010
The discovery of superoxide dismutases (SODs), which convert superoxide radicals to molecular oxygen and hydrogen peroxide, has been termed the most important discovery of modern biology never to win… Expand
Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions.
- Katharine E Hubbard, N. Nishimura, K. Hitomi, E. Getzoff, J. Schroeder
- Biology, Medicine
- Genes & development
- 15 August 2010
The plant hormone abscisic acid (ABA) regulates many key processes in plants, including seed germination and development and abiotic stress tolerance, particularly drought resistance. Understanding… Expand
Identification of a new cryptochrome class. Structure, function, and evolution.
Cryptochrome flavoproteins, which share sequence homology with light-dependent DNA repair photolyases, function as photoreceptors in plants and circadian clock components in animals. Here, we coupled… Expand
Plant UVR8 Photoreceptor Senses UV-B by Tryptophan-Mediated Disruption of Cross-Dimer Salt Bridges
Donuts Dissociate In Arabidopsis, the UVR8 protein responds to ultraviolet-B (UV-B) light by dissociating into monomers, which are then available to interact with downstream factors that enact the… Expand
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Crystal structures of the murine cytokine-inducible nitric oxide synthase oxygenase dimer with active-center water molecules, the substrate L-arginine (L-Arg), or product analog thiocitrulline reveal… Expand
Structural Basis for Isozyme-specific Regulation of Electron Transfer in Nitric-oxide Synthase*[boxs]
- E. Garcin, C. Bruns, +6 authors E. Getzoff
- Medicine, Biology
- Journal of Biological Chemistry
- 3 September 2004
Three nitric-oxide synthase (NOS) isozymes play crucial, but distinct, roles in neurotransmission, vascular homeostasis, and host defense, by catalyzing Ca2+/calmodulin-triggered NO synthesis. Here,… Expand
Structure of a Protein Photocycle Intermediate by Millisecond Time-Resolved Crystallography
The blue-light photoreceptor photoactive yellow protein (PYP) undergoes a self-contained light cycle. The atomic structure of the bleached signaling intermediate in the light cycle of PYP was… Expand