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New biologically active pregnan-21-oic acid esters.
TLDR
Several pregnan-21-oic acid esters possess the unique activity that they are topical anti-inflammatory agents with no side effects and even when administered at high dosages, the usual systemic activity associated with corticosteroid treatment could not be observed.
Studies of the kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4-oestren-3-one-7-3H (norethisterone enanthate) in humans following intramuscular injection.
TLDR
The kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4-oestren-3-one-7-3H (7- 3H-norethisterone enanthate, NET-En) after i.m. injection in two female subjects is described and the subjects eliminated about 60% and 55% of the radioactivity with urine and faeces within 42 days.
[Metabolism and effect of dimethyl sulfoxide].
THE METABOLISM OF DIMETHYL SULFOXIDE AND ITS METABOLIC EFFECTS IN MAN AND ANIMALS
TLDR
The following in vitro studies were done to get some information about the ability of different tissues to bind DMSO and about the important question, whether or not D MSO might accumulate in any of the tissues studied.
In vitro studies on enzymatic cleavage of steroid esters in the female organism.
TLDR
Investigation of steriod ester cleaving enzyme activity of human subcutaneous fatty tissue found marked differences in the relation of the cleavage rate of long- and short-chain steoid esters in the various tissues allow the assumption that long-and-short-chain steroid esters are cleaved by different enzymes to be assumed.
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