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New biologically active pregnan-21-oic acid esters.
Several pregnan-21-oic acid esters possess the unique activity that they are topical anti-inflammatory agents with no side effects and even when administered at high dosages, the usual systemic activity associated with corticosteroid treatment could not be observed.
Studies of the kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4-oestren-3-one-7-3H (norethisterone enanthate) in humans following intramuscular injection.
The kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4-oestren-3-one-7-3H (7- 3H-norethisterone enanthate, NET-En) after i.m. injection in two female subjects is described and the subjects eliminated about 60% and 55% of the radioactivity with urine and faeces within 42 days.
Collection efficiency of aerosol particles by raindrops
[Metabolism and effect of dimethyl sulfoxide].
THE METABOLISM OF DIMETHYL SULFOXIDE AND ITS METABOLIC EFFECTS IN MAN AND ANIMALS
The following in vitro studies were done to get some information about the ability of different tissues to bind DMSO and about the important question, whether or not D MSO might accumulate in any of the tissues studied.
Effects of pituitary hormones and corticosterone on lipolysis in hypophysectomized rats.
Synthesis of novel anti-inflammatory steroids.
In vitro studies on enzymatic cleavage of steroid esters in the female organism.
Investigation of steriod ester cleaving enzyme activity of human subcutaneous fatty tissue found marked differences in the relation of the cleavage rate of long- and short-chain steoid esters in the various tissues allow the assumption that long-and-short-chain steroid esters are cleaved by different enzymes to be assumed.
Comparative studies on the enzymatic cleavage of steroid esters in different tissues of the rat and in adipose human tissue.