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Detection of P-glycoprotein isoforms by gene-specific monoclonal antibodies.
TLDR
It is suggested that the P-glycoprotein isoforms have distinct physiological roles associated with specialized cell functions associated with specialty cell functions. Expand
Identification of a sister gene to P-glycoprotein.
TLDR
A novel gene closely related to the Pgps expressed in the pig and other mammalian liver is identified which is called Sister of P-glycoprotein (spgp), and sequence of this gene shows it to be a member of the ATP-binding cassette family of transporters and the gene most closelyrelated to Pgp identified to date. Expand
Functional Similarities and Differences between Candida albicans Cdr1p and Cdr2p Transporters
TLDR
Interestingly, Cdr1p was found to confer hypersusceptibility to FK520, an immunosuppressant and antifungal agent, whereas Cdr2p conferred resistance to this compound, uncovering a major functional difference between the two transporters. Expand
Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.
TLDR
It is suggested that the epitope of MRK-16 is discontinuous and that the sequences involved which are separated by about 625 amino acids in the linear sequence must be spatially situated in close proximity in the native protein. Expand
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.
TLDR
Comparisons with other MDR-reversing agents showed that IVM is 4- and 9-fold more potent than cyclosporin A and verapamil, respectively and the capacity of IVM to inhibit iodoaryl-azidoprazosin photolabeling of P- gp is consistent with direct binding to P-gp. Expand
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda.
TLDR
An ethnopharmacological investigation was conducted among the Baka pygmies of Dja biosphere reserve (Cameroon) to collect information on the antimalarial plants used in their daily life, and extracts of H. floribunda showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum. Expand
The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain.
TLDR
A novel photoreactive azido analogue of LTC(4) (AALTC( 4) is synthesized and characterized and shown to provide the first direct evidence for LTC (4) binding within MSD0. Expand
Arginine482 to threonine mutation in the breast cancer resistance protein ABCG2 inhibits rhodamine 123 transport while increasing binding.
TLDR
The results of this study provide the first demonstration of the direct binding of drugs to ABCG2, which bound directly to IAARh123. Expand
Major Photoaffinity Drug Binding Sites in Multidrug Resistance Protein 1 (MRP1) Are within Transmembrane Domains 10–11 and 16–17*
TLDR
The results in this study provide the first delineation of the drug binding site(s) of MRP1 and suggest the presence of common drug binding sites for structurally dissimilar drugs. Expand
Functional expression of multidrug resistance protein 1 in Pichia pastoris.
TLDR
The successful expression of catalytically active and transport-competent MRP 1 in P. pastoris should greatly facilitate the efficient production and isolation of the wild type or inactive mutants of MRP1, or of other MRP proteins for structural and functional characterization. Expand
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