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Isolation of exosomes by differential centrifugation: Theoretical analysis of a commonly used protocol
TLDR
To simplify this “cut-off”-size-based adjustment of centrifugation protocol for any rotor, a web-calculator is developed and measured by the nanoparticle tracking analysis (NTA) technique, the concentration and size distribution of the vesicles after centrifugations agree with those theoretically expected. Expand
Genome-scale analysis of DNA methylation in colorectal cancer using Infinium HumanMethylation450 BeadChips
TLDR
A large number of loci with novel differential methylation statuses are reported, some of which may serve as candidate markers for diagnostic purposes, including SND1, ADHFE1, OPLAH, TLX2, C1orf70, ZFP64, NR5A2, and COL4A, which are known to be cancer-specific. Expand
No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes
TLDR
This study did not identify a panel of genomic variants common to these elite endurance athlete groups, and since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Expand
Matrix-Assisted Laser Desorption Ionization-Time of Flight (Mass Spectrometry) for Hepatitis C Virus Genotyping
TLDR
A new accurate and efficient method for HCV genotyping based on minisequencing followed by mass spectrometry is proposed, which is likely to provide more rapid and cheaper forms of testing. Expand
Nucleotide sequence of carnation ringspot dianthovirus RNA-1.
TLDR
The identification of a shifty heptanucleotide preceding the p27 ORF termination codon and a predicted secondary structure following the terminator suggest that a translational frameshifting event allows translation to continue past the p 27 ORF into the p54 ORF, which is in the -1 frame, generating an 88K fusion protein. Expand
The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes
TLDR
The A/A genotype of the FTO T > A polymorphism is under-represented in athletes more reliant on a lean phenotype and associated with decreased proportion of slow-twitch muscle fibers, while is over- represented in strength and heavier athletes. Expand
Detection and characterization of defective interfering RNAs associated with the cocksfoot mottle sobemovirus
TLDR
A new RNA of about 900 nt was found in the virions of cocksfoot mottle virus and in infected plants by RNA hybridization and RT-PCR, and it was assumed totrans-activate synthesis of the CP subgenomic RNA (sgRNA). Expand
AGTR2 gene polymorphism is associated with muscle fibre composition, athletic status and aerobic performance
TLDR
It is shown that the AGTR2 rs11091046 C allele is associated with an increased proportion of slow‐twitch muscle fibres, endurance athlete status and aerobic performance, which has important implications for the understanding of muscle function in both health and disease. Expand
UBR5 is a Novel E3 Ubiquitin Ligase involved in Skeletal Muscle Hypertrophy and Recovery from Atrophy
TLDR
It is suggested that UBR5 is a novel E3 ubiquitin ligase that is inversely regulated to MuRF1/MAFbx, is epigenetically regulated, and is elevated at both the gene expression and protein level during recovery from skeletal muscle atrophy and hypertrophy. Expand
The association of HFE gene H63D polymorphism with endurance athlete status and aerobic capacity: novel findings and a meta-analysis
TLDR
It is shown that the HFE H63D polymorphism is strongly associated with elite endurance athlete status, regardless ethnicities and aerobic capacity in Russian athletes. Expand
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