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Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
Endocannabinoid signaling system and brain reward: Emphasis on dopamine
- E. Gardner
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 1 June 2005
Relapse to Cocaine-Seeking After Hippocampal Theta Burst Stimulation
- S. R. Vorel, Xinhe Liu, Robert J. Hayes, Jordan Spector, E. Gardner
- Psychology, BiologyScience
- 11 May 2001
A dissociation of neural systems subserving positive reinforcement (self-stimulation) and incentive motivation (relapse) is suggested in relapse to cocaine abuse.
Addiction and brain reward and antireward pathways.
- E. Gardner
- Biology, PsychologyAdvances in psychosomatic medicine
The 'bio-psycho-social' model of etiology holds very well for addiction, and addiction appears to correlate with a hypodopaminergic dysfunctional state within the reward circuitry of the brain.
Brain Cannabinoid CB2 Receptors Modulate Cocaine’s Actions in Mice
It is suggested that brain CB2 receptors modulate cocaine's rewarding and locomotor-stimulating effects, likely by a dopamine-dependent mechanism.
Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis
- Jianping Chen, W. Paredes, Jin Li, Diane M. Smith, J. Lowinson, E. Gardner
- 1 October 1990
The present data raise the possibility that marijuana's rewarding effects, and hence its euphorigenic effects and abuse potential, may be related to pharmacological augmentation of presynaptic DA mechanisms.
Cannabinoid CB1 Receptor Antagonist AM251 Inhibits Cocaine-Primed Relapse in Rats: Role of Glutamate in the Nucleus Accumbens
- Z. Xi, Jeremy G. Gilbert, Xiao-Qing Peng, Arlene C. Pak, Xia Li, E. Gardner
- Biology, ChemistryThe Journal of Neuroscience
- 16 August 2006
It is found that systemic administration of AM251 selectively inhibited cocaine-induced, but not sucrose plus sucrose cue- induced, reinstatement of reward-seeking behavior and these effects appear to be mediated by activation of presynaptic mGluR2/3 autoreceptors secondary to AM251-induced increase (disinhibition) of NAc glutamate release.
PG01037, a novel dopamine D3 receptor antagonist, inhibits the effects of methamphetamine in rats
- Amanda E. Higley, Krista J Spiller, E. Gardner
- Biology, PsychologyJournal of psychopharmacology
- 1 February 2011
The data suggest that the novel D3 antagonist PG01037 significantly attenuates the rewarding effects as assessed by progressive-ratio self-administration and brain stimulation reward, and inhibits methamphetamine-associated cue-induced reinstatement of drug-seeking behavior These findings support the potential use of PG010 37 or other selective D3 antagonists in the treatment of methamphetamine addiction.
Conditioned place preference induced by delta 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward.
Cannabinoid Transmission and Reward-Related Events
It is now clear that cannabinoids activate these brain substrates and influence reward-related behaviors, and derive both the abuse potential of cannabinoids and the possible clinical efficacy in dysphoric states.