E. Galun

Publications232
h-index53
Citations12,809
Highly Influential Citations374
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NF-kappaB functions as a tumour promoter in inflammation-associated cancer.
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, the… Expand
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Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness.
Infusion of either embryonic or mesenchymal stem cells prolongs the survival of organ transplants derived from stem cell donors and prevents graft-versus-host-disease (GVHD). An in-depth mechanistic… Expand
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NF-κB functions as a tumour promoter in inflammation-associated cancer
The causes of sporadic human cancer are seldom recognized, but it is estimated that carcinogen exposure and chronic inflammation are two important underlying conditions for tumour development, the… Expand
  • 1,932
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The H19 Non-Coding RNA Is Essential for Human Tumor Growth
Background Mutations and epigenetic aberrant signaling of growth factors pathways contribute to carcinogenesis. Recent studies reveal that non-coding RNAs are controllers of gene expression. H19 is… Expand
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Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis
Hormone refractory metastatic prostate cancer remains an incurable disease. We found that high expression levels of the chemokine receptor CXCR4 correlated with the presence of metastatic disease in… Expand
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Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme.
We undertook a Phase I/II trial in patients with apparent recurrent glioblastoma multiforme (GBM) based on imaging studies to determine the safety and tumor response of repetitive intravenous… Expand
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Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis
Background The highly upregulated in liver cancer (HULC) gene transcribes to an mRNA-like noncoding RNA (ncRNA) by the RNA polymerase II and processed by capping, splicing and polyadenylation. It is… Expand
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The oncofetal H19 RNA connection: hypoxia, p53 and cancer.
Expression of the imprinted H19 gene is remarkably elevated in a large number of human cancers. Recently, we reported that H19 RNA is up-regulated in hypoxic stress and furthermore, it possesses… Expand
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IL-6/IL-6R axis plays a critical role in acute kidney injury.
The response to tissue injury involves the coordination of inflammatory and repair processes. IL-6 expression correlates with the onset and severity of acute kidney injury (AKI), but its contribution… Expand
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Mutant KRAS is a druggable target for pancreatic cancer
Significance Pancreatic cancer is still one of the major challenges in clinical oncology. Mutant KRAS is a driving oncogene in the majority of human pancreatic cancer cases. We have made an effort to… Expand
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