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Transcription factors: from enhancer binding to developmental control
Developmental progression is driven by specific spatiotemporal domains of gene expression, which give rise to stereotypically patterned embryos even in the presence of environmental and geneticExpand
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Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development
Chromatin modifications are associated with many aspects of gene expression, yet their role in cellular transitions during development remains elusive. Here, we use a new approach to obtain cellExpand
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Gene Expression During the Life Cycle of Drosophila melanogaster
Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of allExpand
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Combinatorial binding predicts spatio-temporal cis-regulatory activity
Development requires the establishment of precise patterns of gene expression, which are primarily controlled by transcription factors binding to cis-regulatory modules. Although transcription factorExpand
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A core transcriptional network for early mesoderm development in Drosophila melanogaster.
Embryogenesis is controlled by large gene-regulatory networks, which generate spatially and temporally refined patterns of gene expression. Here, we report the characteristics of the regulatoryExpand
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A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development.
Dissecting components of key transcriptional networks is essential for understanding complex developmental processes and phenotypes. Genetic studies have highlighted the role of members of the Mef2Expand
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Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila.
Polycomb group (PcG) proteins form conserved regulatory complexes that modify chromatin to repress transcription. Here, we report genome-wide binding profiles of PhoRC, the Drosophila PcG proteinExpand
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A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
Cell fate decisions are driven through the integration of inductive signals and tissue-specific transcription factors (TFs), although the details on how this information converges in cis remainExpand
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Enhancer loops appear stable during development and are associated with paused polymerase
Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. Despite their importance, the properties governingExpand
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Patterns of Gene Expression During Drosophila Mesoderm Development
The transcription factor Twist initiates Drosophilamesoderm development, resulting in the formation of heart, somatic muscle, and other cell types. Using a Drosophila embryo sorter, we isolatedExpand
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