Defining the Epithelial Stem Cell Niche in Skin
It is found that these cells rarely divide within their niche but change properties abruptly when stimulated to exit, and their transcriptional profile is determined, which, when compared to progeny and other SCs, defines the niche.
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.
It is demonstrated that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation, revealing the existence of positive and negative regulators of these factors in the skin and unveiling the importance of activated LEF/ TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place.
Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion
Intermediate filaments: structure, dynamics, function, and disease.
A two-step mechanism for stem cell activation during hair regeneration.
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
It is shown that basal epidermal cells use their polarity to divide asymmetrically, generating a committed suprabasal cell and a proliferative basal cell and it is demonstrated that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3–LGN–Inscuteable complex and NuMA–dynactin to align the spindle.
Socializing with the Neighbors Stem Cells and Their Niche
Programming gene expression in developing epidermis.
A modified method of whole-mount in situ hybridization was used to track skin-specific expression of endogenous keratin mRNAs throughout embryogenesis, and it was demonstrated that AP2 has a strong inductive effect on basal keratin expression in a cellular environment that does not normally possess AP2 activity.
Self-Renewal, Multipotency, and the Existence of Two Cell Populations within an Epithelial Stem Cell Niche