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Effectiveness and cost of olanzapine and haloperidol in the treatment of schizophrenia: a randomized controlled trial.
Olanzapine does not demonstrate advantages compared with haloperidol (in combination with prophylactic benztropine) in compliance, symptoms, extrapyramidal symptoms, or overall quality of life, and its benefits in reducing akathisia and improving cognition must be balanced with the problems of weight gain and higher cost.
Severity of symptoms in chronically institutionalized geriatric schizophrenic patients.
- M. Davidson, Philip D. Harvey, E. Frecska
- Psychology, MedicineThe American journal of psychiatry
- 1 February 1995
The older schizophrenic patients continued to experience psychotic and nonpsychotic symptoms in senescence and Somatic treatment appeared not to be responsible for the severe cognitive impairment and negative symptoms of the older patients.
The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization
The therapeutic effects of ayahuasca are best understood from a bio-psycho-socio-spiritual model, and on the biological level ayahuaco may act against chronic low grade inflammation and oxidative stress via the Sig-1R which can explain its widespread therapeutic indications.
Ventricular Enlargement in Poor-Outcome Schizophrenia
Enhancement of Creative Expression and Entoptic Phenomena as After-Effects of Repeated Ayahuasca Ceremonies
This naturalistic study supports the notion that some measures of visual creativity may increase after ritual use of ayahuasca, when the acute psychoactive effects are receded and demonstrates an increased entoptic activity after repeatedAyahuasca ingestion.
Regional brain metabolic response to lorazepam in alcoholics during early and late alcohol detoxification.
- N. Volkow, G. Wang, K. Piscani
- Medicine, PsychologyAlcoholism, clinical and experimental research
- 1 October 1997
The fact that there was only a trend of significance for an abnormal response to lorazepam in orbitofrontal cortex in alcoholics indicates that mechanisms other than GABA are involved in the brain metabolic abnormalities observed in alcoholic subjects.
The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases
The sigma-1 receptor (Sig-1R), a well-known ER-chaperone localizes in the MAM, serves for Ca2+-signaling between the ER and mitochondria, involved in ion channel activities and especially important during neuronal differentiation, and acts as central modulator in inter-organelle signaling.
A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity
- E. Frecska, A. Szabo, M. Winkelman, L. E. Luna, D. Mckenna
- BiologyJournal of Neural Transmission
- 26 April 2013
N,N-dimethyltryptamine (DMT) is classified as a naturally occurring serotonergic hallucinogen of plant origin. It has also been found in animal tissues and regarded as an endogenous trace amine…
Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization
Effects of ayahuasca on binocular rivalry with dichoptic stimulus alternation
It is discussed that ayahuasca-induced survival of binocular rivalry at high DSA rates may be related to slow visual processing and increased mean dominance periods may result from hallucinogen-induced alteration of gamma oscillations in the visual pathways.