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Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination
A T cell subset that emerges in blood after seasonal influenza vaccinations correlates with the development of protective antibody responses. What Lies Beneath Although the seasonal flu vaccine,Expand
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Conserved herpesviral kinase promotes viral persistence by inhibiting the IRF-3-mediated type I interferon response.
A conserved herpesviral kinase, designated ORF36 in murine gamma-herpesvirus 68 (MHV-68), plays multiple vital roles in the viral life cycle. Here, we show by screening mutant viruses that ORF36Expand
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Plasticity and Virus Specificity of the Airway Epithelial Cell Immune Response during Respiratory Virus Infection
ABSTRACT Airway epithelial cells (AECs) provide the first line of defense in the respiratory tract and are the main target of respiratory viruses. Here, using oligonucleotide and protein arrays, weExpand
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Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells
ABSTRACT Interferons (IFNs) are a critical component of the first line of antiviral defense. The activation of Toll-like receptors (TLRs) expressed by dendritic cells triggers different signalingExpand
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γ-Herpesvirus Latency Is Preferentially Maintained in Splenic Germinal Center and Memory B Cells
The γ-herpesviruses are oncogenic B cell lymphotrophic viruses that establish life-long latency in the host. Murine γ-herpesvirus 68 (MHV-68) infection of mice represents a unique system forExpand
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Respiratory Syncytial Virus Uses CX3CR1 as a Receptor on Primary Human Airway Epithelial Cultures
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory disease in infants, but no vaccine or effective therapy is available. The initiation of RSV infection of immortalizedExpand
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Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo
ABSTRACT Type I interferon (IFN) induction is an immediate response to virus infection, and very high levels of these cytokines are produced when the Toll-like receptors (TLRs) expressed at highExpand
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Murid Herpesvirus 4 Strain 68 M2 Protein Is a B-Cell-Associated Antigen Important for Latency but Not Lymphocytosis
ABSTRACT This work describes analyses of the function of the murid herpesvirus 4 strain 68 (MHV-68) M2 gene. A frameshift mutation was made in the M2 open reading frame that caused prematureExpand
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Lambda Interferon Is the Predominant Interferon Induced by Influenza A Virus Infection In Vivo
ABSTRACT The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host defense against influenza A virus infection, but we have now discovered that the recently identifiedExpand
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Antibody-mediated control of persistent gamma-herpesvirus infection.
The human gamma-herpesviruses, EBV and Kaposi's sarcoma-associated herpesvirus, establish life-long latency and can reactivate in immunocompromised individuals. T cells play an important role inExpand
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