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Neuropathic pain in rheumatoid arthritis
TLDR
In patients with a RA exacerbation, chronic pain syndrome is caused not only by an active inflammatory process in the joint area and adjacent tissues, but also by somatosensory nervous system injury and central sensitization.
[The efficacy of meloxicam in acute back pain: results of an observational non-interventional multicenter study].
TLDR
Meloxicam in a dose of 15 mg/day is an effective and safe therapy for the treatment of acute NSBP and the analgesic effect of NSAIDs is higher in young patients, patients with the first episode of NBC and a good response to NSAIDs in history.
Contribution of neurogenic mechanisms to the pathogenesis of chronic joint pain
TLDR
The effectiveness of anticonvulsant is demonstrated in the complex therapy of chronic articular pain in RA and OAk, which confirms the role of central sensitization in the pathogenesis of pain in these diseases.
“Post-COVID syndrome”: The focus is on musculoskeletal pain
TLDR
The main elements of PCS are chronic pain, fatigue, and psychoemotional problems, which can cause the development and exacerbation of diseases characterized by chronic pain and fatigue, such as fibromyalgia and chronic fatigue syndrome.
[Control of pain in the early post-traumatic period in the outpatient practice. Results of the multi-center observational study RAPTOR (Rational Analgesia PostTraumatic: an Observational Research)].
TLDR
PTP decreases rapidly in most patients after a radius fracture, injury of the knee, and ankle ligament injury while taking the original meloxicam, however, in a significant part of patients, moderate or severe PTP persists after 48 weeks, which requires prolonged analgesic therapy and active rehabilitation.
An old friend: 25 years of meloxicam use in Russia.
TLDR
A series of large-scale, well-organized randomized controlled trials and observational post-registration studies have confirmed the good efficacy and low incidence of adverse reactions when using meloxicam.
[What factors affect the effectiveness of long - term analgesic therapy for osteoarthritis? Data analysis of the multi - center 3-month PARACELSUS study].
TLDR
Gender, body mass index ≥30 kg/m2, type 2 diabetes mellitus, poor effect of non - steroidal anti - inflammatory drugs (NSAIDs) and Symptomatic Slow-Acting Drugs in Osteoarthritis (SYSADOA) in history did not affect the result.
Long-term use of nonsteroidal anti-inflammatory drugs for pain control in patients with osteoarthritis: results of the 12-month observational study AELITA (Analgesia: Effective Treatment Using The
TLDR
Aceclofenac is an effective and relatively safe drug for the long-term management of chronic pain in OA and ARs were observed in about 30% of patients, mainly mild or moderate dyspepsia and arterial hypertension.
Regular use of non-steroidal anti-inflammatory drugs can effectively control pain and global health in patients with moderate activity of rheumatoid arthritis
TLDR
Aceclofenac is not inferior to other NSAIDs in analgesic potential and exceeds them in tolerability and can effectively control the pain and other symptoms of RA, as well as the disease activity by DAS28 in patients with moderate or low disease activity.
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