• Publications
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A Syntaxin 1, Gαo, and N-Type Calcium Channel Complex at a Presynaptic Nerve Terminal: Analysis by Quantitative Immunocolocalization
Presynaptic CaV2.2 (N-type) calcium channels are subject to modulation by interaction with syntaxin 1 and by a syntaxin 1-sensitive GαO G-protein pathway. We used biochemical analysis of neuronalExpand
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Single-domain/bound calcium hypothesis of transmitter release and facilitation.
1. We describe a model of transmitter release that is based on the finding that release can be gated during the opening of individual Ca2+ channels, suggesting that the release site can be activatedExpand
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A small-molecule screen in C. elegans yields a new calcium channel antagonist
Small-molecule inhibitors of protein function are powerful tools for biological analysis and can lead to the development of new drugs. However, a major bottleneck in generating useful small-moleculeExpand
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Characterization of a calcium current in a vertebrate cholinergic presynaptic nerve terminal
Calcium currents were recorded from a cholinergic presynaptic nerve terminal in the chick ciliary ganglion using the whole-cell voltage- clamp technique. The presynaptic element of this synapse is inExpand
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N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release
Presynaptic terminals favor intermediate-conductance CaV2.2 (N type) over high-conductance CaV1 (L type) channels for single-channel, Ca2+ nanodomain–triggered synaptic vesicle fusion. However, theExpand
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The Nanophysiology of Fast Transmitter Release
  • E. F. Stanley
  • Medicine, Psychology
  • Trends in Neurosciences
  • 1 March 2016
Action potentials invading the presynaptic terminal trigger discharge of docked synaptic vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting calcium ions (Ca(2+)), whichExpand
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Cleavage of syntaxin prevents G-protein regulation of presynaptic calcium channels
Neurotransmitter release into the synapse is stimulated by calcium influx through ion channels that are closely associated with the transmitter release sites1,2. This link may involve the membraneExpand
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Magainin 2, a natural antibiotic from frog skin, forms ion channels in lipid bilayer membranes.
We have examined the ion channel forming properties of magainin 2 by incorporating the peptide into artificial lipid bilayers held under voltage clamp. Magainin 2 increased lipid bilayer conductanceExpand
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Na/Ca Exchanger and PMCA Localization in Neurons and Astrocytes
Abstract: Immunocytochemistry reveals that the Na/Ca exchanger (NCX) in neuronal somata and astrocytes is confined to plasma membrane (PM) microdomains that overlie sub‐PM (junctional) endoplasmicExpand
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Decline in calcium cooperativity as the basis of facilitation at the squid giant synapse
  • E. F. Stanley
  • Biology, Medicine
  • The Journal of neuroscience : the official…
  • 1 March 1986
The role of Ca in transmitter release and facilitation has been examined at the squid giant synapse by evaluating the effect of changes in the external concentration of Ca on the excitatoryExpand
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