• Publications
  • Influence
The bioavailability of intranasal and smoked methamphetamine
Patients in harm‐reduction treatment programs are switching from intravenous to otherroutes of methamphetamine (INN, metamfetamine) administration to avoid risks associated with needle use.Expand
Human Pharmacology of the methamphetamine stereoisomers
To help predict the consequences of precursor regulation, we compared the pharmacokinetics and pharmacodynamics of the methamphetamine (INN, metamfetamine) stereoisomers.
The pharmacology of cocaethylene in humans following cocaine and ethanol administration.
BACKGROUND Concurrent use of cocaine and alcohol results in formation of a cocaine homolog and metabolite-cocaethylene. METHODS To characterize cocaethylene pharmacology, ten paid volunteerExpand
Bioavailability of Sublingual Buprenorphine
Buprenorphine administered sublingually is a promising treatment for opiate dependence. Utilizing a new, sensitive, and specific gas chromatographic electron‐capture detector assay, the absoluteExpand
Buprenorphine Pharmacokinetics: Relative Bioavailability of Sublingual Tablet and Liquid Formulations
Buprenorphine is an effective new treatment for opiate dependence. This study compared the bioavailability of buprenorphine from a tablet to that from a reference solution. Six men experienced with,Expand
Cocaethylene formation following ethanol and cocaine administration by different routes.
Ethanol alters the hepatic biotransformation of cocaine, resulting in transesterification to a novel active metabolite, cocaethylene. Because of first pass metabolism, oral drug administration mightExpand
Stereochemistry of 1-(4'-hydroxyphenyl)ethanol produced by hydroxylation of 4-ethylphenol by p-cresol methylhydroxylase.
Enzymic hydroxylation of 4-ethylphenol by (a) Pseudomonas putida and (b) highly purified p-cresol methylhydroxylase gave optically active 1-(4'-hydroxyphenyl)-ethanol. The products were transformedExpand
Characterization of cannabidiol-mediated cytochrome P450 inactivation.
Cannibidiol (CBD) has been shown to impair hepatic drug metabolism in several animal species and to markedly inhibit mouse hepatic microsomal delta 1-tetrahydrocannabinol (THC) metabolism byExpand
Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol.
Cannabidiol (CBD) has been shown to be a selective inactivator of cytochromes P450 (P450s) 2C and 3A in the mouse and, like many P450 inactivators, it can also induce P450s after repeatedExpand
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial
RationaleSalvinorin A (SA) is a highly selective kappa opioid receptor agonist and the putative psychoactive compound in Salvia divinorum (SD), an increasingly abused hallucinogenicExpand