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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations. Expand
Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle
This first completed genome for a human-associated TM7 phylotype revealed a complete lack of amino acid biosynthetic capacity, and comparative genomics analyses with uncultivated environmental TM7 assemblies show remarkable conserved gene synteny and only minimal gene loss/gain that may have occurred as TM7x adapted to conditions within the human host. Expand
Evidence for Ectopic Neurotransmission at a Neuronal Synapse
Simulated synaptic activity is consistent with experimental recordings of miniature excitatory postsynaptic currents only when ectopic transmission is included in the model, broadening the possibilities for mechanisms of neuronal communication. Expand
Single Cell Genome Amplification Accelerates Identification of the Apratoxin Biosynthetic Pathway from a Complex Microbial Assemblage
This work represents the first successful isolation of a complete biosynthetic gene cluster from Lyngbya bouillonii, a tropical marine cyanobacterium renowned for its production of diverse bioactive secondary metabolites. Expand
Sharing and community curation of mass spectrometry data with GNPS
The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP communityExpand
Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages
To use the molecular machinery responsible for the biosynthesis of potential drug-lead natural products, new tools must be applied to delineate their genetic and enzymatic origins. Expand
Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy.
The principles behind molecular networking are highlighted and its use for the discovery of therapeutic leads, monitoring drug metabolism, clinical diagnostics, and emerging applications in precision medicine are highlighted. Expand
Significant Natural Product Biosynthetic Potential of Actinorhizal Symbionts of the Genus Frankia, as Revealed by Comparative Genomic and Proteomic Analyses
Bioinformatic analysis of the genome sequences of Frankia strains ACN14a, CcI3, and EAN1pec revealed an unexpected number of secondary metabolic biosynthesis gene clusters, demonstrating species-specific biosynthetic diversity and presenting a clear roadmap for natural products discovery in the Frankia genus. Expand
Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya.
Polyphyly of morphologically similar cyanobacteria was identified as the major explanation for the perceived chemical richness of the genus Lyngbya, a result which further underscores the need to revise the taxonomy of this group of biomedically important cyanob bacteria. Expand
Imaging mass spectrometry of natural products.
Three different imaging mass spectrometry approaches, MALDI, DESI and SIMS and their recent applications in the analysis of natural products are described. Expand