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Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines
- K. Kisand, Anette S Bøe Wolff, A. Meager
- Medicine, BiologyThe Journal of experimental medicine
- 15 February 2010
It is concluded that IL-22 and IL-17F are key natural defenders against CMC and that the immunodeficiency underlying CMC in both patient groups has an autoimmune basis.
Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cell.
- Ø. Bruserud, C. Stapnes, E. Ersvaer, B. Gjertsen, A. Ryningen
- Biology, MedicineCurrent pharmaceutical biotechnology
Divergent effects of HDAC inhibition on the global gene expression profiles have been described when testing various cancer cells, and this is further complicated by altered HDAC expression induced by HDAC inhibitors.
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells
- E. Ersvaer, K. Liseth, J. Skavland, B. Gjertsen, Ø. Bruserud
- Biology, MedicineBMC Immunology
- 9 July 2010
The effect of intensive AML chemotherapy differ between circulating T cell subsets, relative frequencies of TH17 cells are not affected by chemotherapy and this subset may affect AML cells indirectly through their immunoregulatory effects but probably not through direct effects of IL17-A.
Heat shock protein 90 - a potential target in the treatment of human acute myelogenous leukemia.
The results from these initial studies have documented that HSP90 inhibition can mediate antileukemic effects in vivo, however, one would expect immunosuppressive side effects because H SP90 inhibitors have both direct and indirect inhibitory effects on T cell activation.
Interleukin-6 in Allogeneic Stem Cell Transplantation: Its Possible Importance for Immunoregulation and As a Therapeutic Target
The current understanding of how pro-inflammatory IL-6 effects exerted during the peritransplant period shapes T-cell polarization with enhancement of Th17 differentiation and suppression of regulatory T cells is summarized, and the results from trials exploring non-selective IL- 6 inhibition in prophylaxis and treatment of GVHD are reviewed.
Peripheral Blood Stem Cell Mobilization in Healthy Donors by Granulocyte Colony-Stimulating Factor Causes Preferential Mobilization of Lymphocyte Subsets
- G. Melve, E. Ersvaer, G. Eide, E. Kristoffersen, Ø. Bruserud
- Medicine, BiologyFront. Immunol.
- 2 May 2018
Strong G-CSF-induced mobilization of various T cell subsets seemed to increase the risk of recipient acute graft versus host disease, and this was independent of the graft T cell levels.
Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators
A role for the leukaemic‐endothelium crosstalk in leukaemogenesis with enhancement of endothelial cell growth and increased AML cell proliferation possibly mediated by angiopoietin‐1 and the STAT signalling pathway is indicated.
The Protein Kinase C Agonist PEP005 (Ingenol 3-Angelate) in the Treatment of Human Cancer: A Balance between Efficacy and Toxicity
The diterpene ester ingenol-3-angelate (referred to as PEP005) is derived from the plant Euphorbia peplus. Crude euphorbia extract causes local toxicity and transient inflammation when applied…
Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005)
- P. Hampson, Keqing Wang, Lisa Milverton, E. Ersvaer, O. Bruserud, J. Lord
- 14 May 2010
The data show that PEP005-induced apoptosis is both PKC and ERK1/2 dependent and indicate that chronic activation of ERK 1/2 in leukaemic cells delivers a pro-apoptotic rather than a proliferative or survival signal.
Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat…