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Suppression of conditioned avoidance behavior by the local application of (−)sulpiride into the ventral, but not the dorsal, striatum of the rat
TLDR
It is concluded that the performance of conditioned avoidance behavior in the rat is critically dependent on an intact dopaminergic neurotransmission in the nucleus accumbens or adjacent areas of the ventral striatum. Expand
Photocell measurements of rat motor activity. A contribution to sensitivity and variation in behavioral observations.
TLDR
A new, photocell-equipped, activity meter is described, evaluated by studying the effects of six psychoactive compounds, d-amphetamine, apomorphine, phencyclidine, raclopride, haloperidol, and 8-hydroxy-2-(di-n-propylamino) tetralin. Expand
Suggestive evidence for inhibitory effects of galanin on mesolimbic dopaminergic neurotransmission
TLDR
It is concluded that the neuropeptide galanin modulates forebrain dopaminergic neurotransmission and appears to be mediated at the somato-dendritic level of the meso-neostriatal pathway, and could perhaps be utilized to normalize perturbations ascribed to dysfunction in this neuronal pathway, such as schizophrenia. Expand
Loss of dopamine uptake sites labeled with [3H]GBR-12935 in Alzheimer's disease.
TLDR
It is suggested that the loss of [3H]GBR-12935-binding sites in human putamen in AD/SDAT reflects a degeneration of dopamine neurites. Expand
Behavioural and biochemical effects of subchronic treatment with raclopride in the rat: tolerance and brain monoamine receptor sensitivity.
TLDR
There was an increase in locomotor activity by the apomorphine treatment in animals pretreated with the 8 mg kg-1 dose, as compared to the response obtained in saline controls, and there was an increased DA receptor sensitivity presynaptically as evidenced by an enhanced effect on striatal DOPA levels by apomorphicine in rats treated with NSD 1015 and reserpine. Expand
Loss of discriminative avoidance behavior by local application of kynurenic acid into the nucleus accumbens of the rat
TLDR
Male Sprague-Dawley rats, trained to perform a visual discrimination, were administered kynurenic acid, an antagonist of excitatory amino acid receptors, 4.7 micrograms bilaterally into the nucleus accumbens and results show that this behavior also is dependent on an intact excited amino acid neurotransmission. Expand
Stimulation of brain dopamine autoreceptors by remoxipride administration in reserpine‐treated male rats
TLDR
Reserpine produced a marked increase in striatal and neocortical dopa accumulation, in comparison with glucose vehicle + NSD‐1015‐treated controls, and this increase was dose‐dependently antagonized by remoxipride treatment, which could contribute to the favourable endocrine and extrapyramidal side effect profile of remxipride as an antipsychotic agent. Expand
In vivo effects of remoxipride and aromatic ring metabolites in the rat.
TLDR
Considering remxipride as a nonclozapine atypical antipsychotic drug, together with the fact that remoxipride behaves as a prodrug in the laboratory studies above, further characterization of the pharmacodynamic profile of its metabolites remains a challenge. Expand
In vivo characterization of novel full and partial 2-(4-aminophenyl)-N,N-dipropylethylamine dopamine D(2) receptor agonists.
TLDR
The present series of compounds offer the possibility of adjusting intrinsic efficacy at dopamine D(2) receptors, and such fine-tuning could be an important strategy in the search for optimal antipsychotic or antiparkinson drugs within the partial dopamine D (2) receptor agonist concept. Expand
Scopolamine does not restore normal conditioned avoidance performance in raclopride-treated rats
TLDR
It is concluded that anticholinergics do not restore normal behavior after neuroleptic-induced suppression of conditioned avoidance behavior, as well as of catalepsy, in rats. Expand
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