E. Entcheva

Publications107
h-index30
Citations2,998
Highly Influential Citations75
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Computational Optogenetics: Empirically-Derived Voltage- and Light-Sensitive Channelrhodopsin-2 Model
TLDR
A quantitative model of Channelrhodospin-2, a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. Expand
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Electrospun fine-textured scaffolds for heart tissue constructs.
The structural and functional effects of fine-textured matrices with sub-micron features on the growth of cardiac myocytes were examined. Electrospinning was used to fabricate biodegradable non-woven… Expand
  • 578
  • 10
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Functional cardiac cell constructs on cellulose-based scaffolding.
Cellulose and its derivatives have been successfully employed as biomaterials in various applications, including dialysis membranes, diffusion-limiting membranes in biosensors, in vitro hollow fibers… Expand
  • 235
  • 4
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OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology
TLDR
The improvement of preclinical cardiotoxicity testing, discovery of new ion-channel-targeted drugs, and phenotyping and use of stem cell-derived cardiomyocytes and other biologics all necessitate high-throughput (HT), cellular-level electrophysiological interrogation tools. Expand
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Cardiac optogenetics.
  • E. Entcheva
  • Medicine
  • American journal of physiology. Heart and…
  • 2013
Optogenetics is an emerging technology for optical interrogation and control of biological function with high specificity and high spatiotemporal resolution. Mammalian cells and tissues can be… Expand
  • 79
  • 4
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Efficient Modeling of Excitable Cells Using Hybrid Automata
TLDR
We present an approach based on hybrid automata (HA), which combine discrete transition graphs with continuous dynamical systems, to modeling complex biological systems. Expand
  • 52
  • 3
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Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self‐organization
In vitro models of cardiac hypertrophy focus exclusively on applying “external” dynamic signals (electrical, mechanical, and chemical) to achieve a hypertrophic state. In contrast, here we set out to… Expand
  • 31
  • 3
Modelling excitable cells using cycle-linear hybrid automata.
Cycle-linear hybrid automata (CLHAs), a new model of excitable cells that efficiently and accurately captures action-potential morphology and other typical excitable-cell characteristics such as… Expand
  • 42
  • 3
  • PDF
Stimulating Cardiac Muscle by Light: Cardiac Optogenetics by Cell Delivery
Background— After the recent cloning of light-sensitive ion channels and their expression in mammalian cells, a new field, optogenetics, emerged in neuroscience, allowing for precise perturbations of… Expand
  • 152
  • 2
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Macroscopic optical mapping of excitation in cardiac cell networks with ultra-high spatiotemporal resolution.
  • E. Entcheva, H. Bien
  • Computer Science, Medicine
  • Progress in biophysics and molecular biology
  • 1 October 2006
TLDR
Optical mapping of cardiac excitation using voltage- and calcium-sensitive dyes has allowed a unique view into excitation wave dynamics, and facilitated scientific discovery in the cardiovascular field. Expand
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