Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors.
- J. Jakubík, L. Bačáková, E. El‐Fakahany, S. Tuček
- Biology, ChemistryMolecular Pharmacology
- 1 July 1997
The discovery that it is possible to increase the affinity of muscarinic receptors for their agonists by allosteric modulators offers a new way to subtype-specific pharmacological enhancement of transmission at cholinergic (muscarinic) synapses.
The assessment of antagonist potency under conditions of transient response kinetics.
An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.
Data demonstrate for the first time that this highly conserved arginine residue plays an important role in coupling of muscarinic receptors to signal transduction mechanisms.
Marked Induction of Calcium-Independent Nitric Oxide Synthase Activity after Focal Cerebral Ischemia
- C. Iadecola, Xiaohong Xu, Fangyi Zhang, E. El‐Fakahany, M. Ross
- Biology, MedicineJournal of Cerebral Blood Flow and Metabolism
- 1 January 1995
The results suggest that the decline in calcium-dependent (cNOS) activity reflects loss of NOS neurons within the lesion, and sustained nitric oxide production by iNOS may contribute to the late phase of tissue damage in focal cerebral ischemia.
NMDA Receptor-Mediated Refinement of a Transient Retinotectal Projection during Development Requires Nitric Oxide
- A. Ernst, H. H. Wu, E. El‐Fakahany, S. McLoon
- Biology, ChemistryJournal of Neuroscience
- 1 January 1999
NMDA receptor-mediated elimination of the ipsilateral retinotectal projection is completely mediated via nitric oxide, suggesting that NMDA receptor activation can regulateNitric oxide synthase activity in the tectum.
Constitutive activity of the M1–M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists
Evidence for a Tandem Two-site Model of Ligand Binding to Muscarinic Acetylcholine Receptors*
Experimental data on [ 3H]NMS and [3H]QNB association and dissociation perfectly agree with the predictions of the tandem two-site model, which support a model in which the receptor binding domain has two tandemly arranged subsites for classical ligands, a peripheral one and a central one.
The Role of Nitric Oxide in Development of Topographic Precision in the Retinotectal Projection of Chick
The results show that nitric oxide is involved in refinement of the topography of the retinotectal projection as well as in other aspects of refinement of this projection in developing chick.
Polyamines inhibit nitric oxide synthase in rat cerebellum
Characterization of the striatal M2 muscarinic receptor mediating inhibition of cyclic AMP using selective antagonists: a comparison with the brainstem M2 receptor.
- M. Mckinney, D. Anderson, C. Forray, E. El‐Fakahany
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 August 1989
The profile of the striatal M2 receptor obtained with a group of selective muscarinic antagonists did not match in all respects with either glandular (pro probable M4 gene product) or cardiac (probable M2 gene product).