• Publications
  • Influence
Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.
TLDR
It is shown that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct cytolytic function independent of TCR specificity in effector CD8 T cells. Expand
Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed
TLDR
The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR/CCR-9, both in T cell development and the mucosal immune response, and proposes the designation CCR-9 for this chemokine receptor. Expand
Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment
TLDR
Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Expand
Cutting Edge: NKG2D Receptors Induced by IL-15 Costimulate CD28-Negative Effector CTL in the Tissue Microenvironment1
  • Arthur I. Roberts, Leanne Lee, +4 authors Bana Jabri
  • Biology, Medicine
  • The Journal of Immunology
  • 15 November 2001
TLDR
This work reports that NKG2D, the receptor for stress-induced MICA and MICB molecules expressed in the intestine, serves as a potent costimulatory receptor for CTL freshly isolated from the human intestinal epithelium, which is regulated by IL-15. Expand
Selective expansion of intraepithelial lymphocytes expressing the HLA-E–specific natural killer receptor CD94 in celiac disease☆☆☆
TLDR
In active celiac disease, there is a specific and selective increase of IELs expressing CD94, the HLA-E–specific NK receptor that may be related to T-cell receptor activation and/or interleukin 15 secretion. Expand
Gastrointestinal Manifestations of Behçet’s Disease
  • E. Ebert
  • Medicine
  • Digestive Diseases and Sciences
  • 1 February 2009
TLDR
Behçet’s disease is a chronic, unpredictable course with exacerbations and remissions which decrease in frequency and severity over time, and death is mainly due to major vessel disease and neurological involvement. Expand
Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation
TLDR
This work shows that the CXCR4 ligand stromal derived factor-1 (SDF-1) is constitutively expressed by mucosal epithelial cells at sites of HIV transmission and propagation, and postulates that mucosally derived SDF- 1 continuously downmodulates CX CR4 on resident HIV target cells, thereby reducing the transmission and propagate of X4-HIV at mucosal sites. Expand
Gastrointestinal and Hepatic Manifestations of Sarcoidosis
TLDR
The overall prognosis is good although most patients will have some permanent organ impairment and Corticosteroids should be instituted when organ function is threatened, usually lungs, eyes, and central nervous system. Expand
Gastrointestinal complications of diabetes mellitus.
  • E. Ebert
  • Medicine
  • Disease-a-month : DM
  • 1 December 2005
TLDR
Evaluation of ardiovascular autonomic function has been used as a surrogate marker of he function of the abdominal vagus in type 2 DM, which varies markedly with the region, being much more ommon in Finland than in Japan or China. Expand
Gastrointestinal Manifestations of Amyloidosis
TLDR
Amyloidosis should be considered in patients with proteinuria, cardiomyopathy, hepatomegaly (with mildly abnormal liver tests), peripheral and autonomic neuropathy, weight loss, and GI symptoms, and treatment for AA amyloidosis is control of the underlying disease. Expand
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