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The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have beenExpand
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CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
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Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
Clinical heterogeneity within t(12;21) or TEL/AML1-positive ALL (25% of childhood common/preB ALL) indicates that additional genetic changes might contribute to outcome. We studied the relationExpand
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Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10
SummaryThe antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reactsExpand
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Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia
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Rapid and sensitive detection of all types of MLL gene translocations with a single FISH probe set
The MLL gene on chromosome 11 band q23 is frequently involved in chromosome translocations in acute lymphoblastic leukemia and acute myeloid leukemia. The translocation results in the formation of aExpand
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ERCC 1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair †
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion 2.6, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213-1863; Department of Microbiology and Molecular Genetics,Expand
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Selective Inhibition of BRCA 2-Deficient MammaryTumor Cell Growth byAZD 2281 and Cisplatin
Purpose: To assess efficacy of the novel, selective poly(ADP-ribose) polymerase-1 (PARP-1) inhibitorAZD2281against newly established BRCA2-deficient mouse mammary tumor cell lines and to determineExpand
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Positional mapping of loci in the DiGeorge critical region at chromosome 22q11 using a new marker (D22S183)
The majority of patients with DiGeorge syndrome (DGS) and velo-cardio-facial syndrome (VCFS) and a minority of patients with non-syndromic conotruncal heart defects are hemizygous for a region ofExpand
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