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- Publications
- Influence
The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks
- K. Hanada, Magda Budzowska, +7 authors R. Kanaar
- Biology, Medicine
- Nature Structural &Molecular Biology
- 14 October 2007
Faithful duplication of the genome requires structure-specific endonucleases such as the RuvABC complex in Escherichia coli. These enzymes help to resolve problems at replication forks that have been… Expand
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
- L. V. Zutven, E. Drunen, +6 authors H. Beverloo
- Medicine
- Leukemia
- 1 July 2005
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
- W. Stams, H. Beverloo, +8 authors R. Pieters
- Biology, Medicine
- Leukemia
- 1 March 2006
Clinical heterogeneity within t(12;21) or TEL/AML1-positive ALL (25% of childhood common/preB ALL) indicates that additional genetic changes might contribute to outcome. We studied the relation… Expand
Assignment of the gene(s) involved in the expression of the proliferation-related Ki-67 antigen to human chromosome 10
- D. Schonk, H. Kuijpers, +4 authors F. Ramaekers
- Biology, Medicine
- Human Genetics
- 1 October 1989
SummaryThe antigen recognized by the monoclonal antibody Ki-67 is a proliferation-related nucleolus-associated constituent used as a marker for cycling cells in tumor diagnosis. Antibody Ki-67 reacts… Expand
T1768 Generation of a Tightly Regulated Doxycycline-Inducible Model for Studying Mouse Intestinal Biology
- S. Roth, P. Franken, +8 authors R. Smits
- Biology
- 1 May 2009
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia
- B. Wouters, M. Sanders, +6 authors R. Delwel
- Biology, Medicine
- Leukemia
- 1 November 2007
Segmental uniparental disomy as a recurrent mechanism for homozygous CEBPA mutations in acute myeloid leukemia
Rapid and sensitive detection of all types of MLL gene translocations with a single FISH probe set
- M. Burg, H. Beverloo, +4 authors J. V. Dongen
- Biology, Medicine
- Leukemia
- 1 December 1999
The MLL gene on chromosome 11 band q23 is frequently involved in chromosome translocations in acute lymphoblastic leukemia and acute myeloid leukemia. The translocation results in the formation of a… Expand
ERCC 1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair †
- A. Ahmad, A. Robinson, +6 authors L. Niedernhofer
- 2008
University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion 2.6, 5117 Centre Avenue, Pittsburgh, Pennsylvania 15213-1863; Department of Microbiology and Molecular Genetics,… Expand
- 30
- PDF
Selective Inhibition of BRCA 2-Deficient MammaryTumor Cell Growth byAZD 2281 and Cisplatin
- Bastiaan Evers, R. Drost, +12 authors J. Jonkers
- 2008
Purpose: To assess efficacy of the novel, selective poly(ADP-ribose) polymerase-1 (PARP-1) inhibitorAZD2281against newly established BRCA2-deficient mouse mammary tumor cell lines and to determine… Expand
- 27
- PDF
Positional mapping of loci in the DiGeorge critical region at chromosome 22q11 using a new marker (D22S183)
- M. P. Mulder, M. Wilke, +9 authors C. Meijers
- Biology, Medicine
- Human Genetics
- 1 August 1995
The majority of patients with DiGeorge syndrome (DGS) and velo-cardio-facial syndrome (VCFS) and a minority of patients with non-syndromic conotruncal heart defects are hemizygous for a region of… Expand