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DNA microarrays for comparative genomic hybridization based on DOP‐PCR amplification of BAC and PAC clones
TLDR
A set of clones selected from the publicly available Golden Path of the human genome at 1‐Mb intervals is described and a view in the Ensembl genome browser from which data required for the use of these clones in array CGH and other experiments can be downloaded across the Internet.
Array Comparative Genomic Hybridization Analysis of Colorectal Cancer Cell Lines and Primary Carcinomas
TLDR
The overall pattern of copy number change was strikingly similar between cell lines and primary cancers with a few obvious exceptions such as loss of chromosome 6 and gain of chromosomes 15 and 12p in the former.
The complex nature of constitutional de novo apparently balanced translocations in patients presenting with abnormal phenotypes
TLDR
Unexpected additional complexity or genome imbalance was found in six of 10 patients studied and provides an argument for the more widespread adoption of microarray analysis or other high resolution genome-wide screens for chromosome imbalance and rearrangement.
Array-CGH analysis of microsatellite-stable, near-diploid bowel cancers and comparison with other types of colorectal carcinoma
TLDR
The data support the suggestion that some MSI−CIN− carcinomas form a qualitatively different group from the other cancer types, and suggest that the MSI− CIN− group is itself heterogeneous.
An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype.
TLDR
DNA samples from a cohort of sporadic BWS patients and healthy controls were genotyped for the DMR0 SNPs, suggesting either a genetic predisposition to LOM or interactions between genotype and epigenotype that impinge on the disease phenotype.
Refining molecular analysis in the pathways of colorectal carcinogenesis.