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Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma.
- A. Murat, E. Migliavacca, M. Hegi
- Medicine, BiologyJournal of clinical oncology : official journal…
- 20 June 2008
This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.
Coupled two-way clustering analysis of gene microarray data.
An algorithm, based on iterative clustering, that performs an algorithm to identify subsets of the genes and samples, such that when one of these is used to cluster the other, stable and significant partitions emerge.
A module of negative feedback regulators defines growth factor signaling
This study addresses the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events ofgrowth factor signaling.
Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification
The analyses provide a novel route to infer expression profiles for presumed ancestral nodes in the tissue dendrogram, whereby de novo enhancement and diminution of gene expression go hand in hand, and highlight the importance of gene suppression events.
Pathway-based personalized analysis of cancer
- Y. Drier, Michal Sheffer, E. Domany
- Computer ScienceProceedings of the National Academy of Sciences
- 1 April 2013
Several pathways that were significantly associated with survival of glioblastoma patients and two whose scores are predictive of survival in colorectal cancer: CXCR3-mediated signaling and oxidative phosphorylation are discovered.
Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer
- Michal Sheffer, M. Bacolod, E. Domany
- BiologyProceedings of the National Academy of Sciences
- 28 April 2009
A statistical analysis of 299 expression and 130 SNP arrays profiled at different stages of colorectal cancer provided the statistical power to show that deletions of 8p, 4p, and 15q are associated with survival and disease progression, and that samples with simultaneous deletions in 18q, 8p and 4p have a particularly poor prognosis.
Equivalence of Cellular Automata to Ising Models and Directed Percolation
Time development of cellular automata in $d$ dimensions is mapped onto equilibrium statistical mechanics of Ising models in $d+1$ dimensions. Directed percolation is equivalent to a cellular…
A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal.
Phase transitions in an exactly soluble one-dimensional exclusion process
We consider an exclusion process with particles injected with rate α at the origin and removed with rate β at the right boundary of a one-dimensional chain of sites. The particles are allowed to hop…
Resampling Method for Unsupervised Estimation of Cluster Validity
A figure of merit that measures the stability of clustering solutions against resampling is introduced, and the applicability of the method for validation of results obtained by clustering analysis of data for higher-dimensional data, including gene microarray expression data.