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Eosinophilic esophagitis: updated consensus recommendations for children and adults.
TLDR
A new conceptual definition is proposed highlighting that EoE represents a chronic, immune/antigen-mediated disease characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Expand
ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)
TLDR
Recommendations developed by adult and pediatric gastroenterologists are provided for the evaluation and management of patients with eosinophilic–esophageal disorders. Expand
Burden of gastrointestinal disease in the United States: 2012 update.
TLDR
The burden of GI disease in the United States is estimated and the most common GI symptom is abdominal pain, while the total cost for outpatient GI endoscopy examinations was $32.4 billion. Expand
Burden of Gastrointestinal, Liver, and Pancreatic Diseases in the United States.
TLDR
The most recent data were obtained from the Centers for Disease Control and Prevention, the Agency for Healthcare Research and Quality, and the National Cancer Institute to estimate the burden and cost of GI and liver disease in the United States. Expand
Prevalence of eosinophilic esophagitis in the United States.
TLDR
Despite its relatively recent description, EoE is frequently diagnosed in the United States, with an estimated prevalence of 56.7/100,000 persons, which depends on the accuracy of the International Classification of Diseases, 9th revision code, but it could be an underestimate. Expand
Clinical and Endoscopic Characteristics do Not Reliably Differentiate PPI-Responsive Esophageal Eosinophilia and Eosinophilic Esophagitis in Patients Undergoing Upper Endoscopy: A Prospective Cohort
TLDR
Although EoE was seen in nearly a quarter of patients with dysphagia, PPI-REE was almost as common, and accounted for over one-third of those with ≥15 eos/hpf, and none were significantly associated with disease status on multivariable analysis. Expand
Desmoglein-1 regulates esophageal epithelial barrier function and immune responses in eosinophilic esophagitis
TLDR
A functional role is identified for DSG1 and its dysregulation by IL-13 in the pathophysiology of EoE and it is suggested that the loss ofDSG1 may potentiate allergic inflammation through the induction of pro-inflammatory mediators such as POSTN. Expand
Anatomical Course of the Lateral Femoral Cutaneous Nerve and Its Susceptibility to Compression and Injury
TLDR
The results of this study suggest that the lateral femoral cutaneous nerve is most susceptible to mechanical trauma when the nerve is type A, B, or C. Expand
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
TLDR
An updated diagnostic algorithm for EoE was developed, with removal of the PPI trial requirement, and the evidence suggests that PPIs are better classified as a treatment for esophageal eosinophilia that may be due to EOE than as a diagnostic criterion. Expand
A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease.
TLDR
In this large EoE cohort, the likelihood of fibrostenotic disease increased markedly with age, and this association suggests that the natural history of Eosinophilic esophagitis is a progression from an inflammatory to a fibrostanotic disease. Expand
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