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Regulation of the number of functional voltage-sensitive Ca++ channels on PC12 cells by chronic changes in membrane potential.
It appears that the number of functional VSCC can be regulated by changes in intracellular Ca++ such as those associated with prolonged depolarization, but because Ca++ channel number remained depressed while intrACEllular free Ca++ returned to normal, other mechanisms controlling channel number also must be involved.
Muscarine-stimulated neurotransmitter release from PC12 cells.
The results suggest that muscarine-stimulated release of neurotransmitter may be associated with an inositol trisphosphate-induced mobilization of intracellular Ca++.
Effects of Prolonged Depolarization on the Nicotinic Acetylcholine Receptors of PC12 Cells
Concurrent depolarization did not affect the functional down‐regulation produced by chronic exposure of the cells to carbachol, and neuronal nicotinic acetylcholine receptors on PC12 cells do not appear to be regulated by depolarized or prolonged elevation of the intracellular Ca2+ level.