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Daisy-chain gene drives for the alteration of local populations
Significance CRISPR-based gene drive systems—genetic elements which could be engineered to rapidly spread traits through wild populations—could help solve some of humanity’s greatest ecological andExpand
Daisy-chain gene drives for the alteration of local populations
RNA-guided gene drive elements could address many ecological problems by altering the traits of wild organisms, but the likelihood of global spread tremendously complicates ethical development andExpand
A high-throughput platform for feedback-controlled directed evolution
We report the design and validation of Phage-and-Robotics-Assisted Near-Continuous Evolution (PRANCE), an automation platform for the continuous directed evolution of biomolecules that enables real-time activitydependent reporter and absorbance monitoring of up to 96 parallel evolution experiments. Expand
Autonomous Navigation System for Spacecraft Using Low-Thrust Trajectories
This research describes a prototype software navigation system that would allow a spacecraft with a small amount of continuous propulsion to navigate low-energy trajectories that rely on the gravitational effects of different two-body systems. Expand
Measuring the tolerance of the genetic code to altered codon size
Protein translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet-codon, rather than quadruplet-codon,Expand
Flexible open-source automation for robotic bioengineering
Liquid handling robots have become a biotechnology staple1,2, allowing laborious or repetitive protocols to be executed in high-throughput. However, software narrowly designed to automate traditionalExpand
The first three rungs of the cosmological distance ladder
It is straightforward to determine the size of the Earth and the distance to the Moon without using a telescope. The methods have been known since the third century BCE. However, few astronomers haveExpand
Enabling high‐throughput biology with flexible open‐source automation
Our understanding of complex living systems is limited by our capacity to perform experiments in high throughput. While robotic systems have automated many traditional hand‐pipetting protocols,Expand