• Publications
  • Influence
Myelin basic protein.
  • E. Day
  • Medicine
    Contemporary topics in molecular immunology
  • 1981
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental
Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex
TLDR
Reaction 1 was the simplest explanation accommodating all the observed facts, and the reaction had been proposed many years earlier by Haber and Weiss during their studies of the catalytic decomposition of hydrogen peroxide by iron salts.
Isolation and characterization of a manganese-containing superoxide dismutase from rat liver.
TLDR
A manganese-containing superoxide dismutase has been purified from rat liver and characterized and metal content, molecular weight, and amino acid analyses show that the rat enzyme is similar to the manganosuperoxide dismUTase isolated from human liver.
Radioimmunoassay of myelin basic protein in sodium sulfate.
TLDR
A radioimmunoassay of myelin basic protein of the rat and guinea pig, based upon precipitation of the 125 I-BP antibody complex in 1·27M Na 2 SO 4, found thatLabeled and unlabeled BP were equally competitive for antibody in regions of antigen excess.
Intact B-cell activity is essential for complete expression of experimental allergic encephalomyelitis in Lewis rats.
Abstract B-Cell activity in weanling Lewis rats was inhibited by injections of goat anti-rat mu-chain antiserum (GAMS) from birth on, as demonstrated by markedly reduced or absent myelin basic
The major heat stable allergen of shrimp.
TLDR
Serum from a patient who had experienced several episodes of anaphylaxis after eating shrimp was used to monitor the isolation of a major allergen from shrimp, which was then tested with sera from 10 other shrimp-reactive patients and was a potent inhibitor of RAST to both cooked and raw shrimp.
The use of paired labeling in the determination of tumor-localizing antibodies.
TLDR
It was found that localization of antibody in the Murphy lymphosarcoma of rats is not uniform and does not parallel localization of normal serum globulin preparations, and that different parts of the tumor have different abilities to absorb antibody.
FACTORS INFLUENCING THE CELL TYPE OF BRAIN TUMORS INDUCED IN DOGS BY SCHMIDT‐RUPPIN ROUS SARCOMA VIRUS
TLDR
In dose-response studies a graded host response with decreasing number of brain tumors per animal as well as decreasing numbers of inoculated animals with tumors was observed with decreasing SR-RSV doses, and brain inoculation site was the determinant of type of tumor induced.
Endogenous myelin basic protein-serum factors (MBP-SFs) and anti-MBP antibodies in humans Occurrence in sera of clinically well subjects and patients with multiple sclerosis
TLDR
Sera of normal subjects and patients wtih multiple sclerosis (MS) have been frequently found to contain picomolar quantities of endogenous myelin basic protein-serum factors (MBP-SFs), and a competitive inhibition radioimmunoassay designed to distinguish their respective binding affinities with anti-MBP reagent antiserum detected and determined.
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