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Comparative study of the biotransformation of bepridil analogs in isolated liver cells from one rat. Relationships between structure and in vitro liver toxicity
- E. Damatte, M. Galmier, C. Lartigue-Mattei, J. Pognat, N. Busch, J. Chabard
- BiologyEuropean Journal of Drug Metabolism and…
- 1 October 1996
The biotransformation of several analogs of the anti-calcium agent bepridil was studied comparatively in liver cells isolated from one rat, finding thatortho-substituted analogs were more toxic thanpara- ormeta-subStituted ones.