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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
TLDR
It is shown that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons, and biochemical studies suggest that VR1 associates with this complex. Expand
A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
TLDR
The PIP2-interaction domain serves as a critical determinant of thermal threshold and dynamic sensitivity range, tuning TRPV1, and thus the sensory neuron, to appropriately detect heat under normal or pathophysiological conditions. Expand
DNA topoisomerase IIbeta and neural development.
TLDR
DNA topoisomerase IIbeta is shown to have an unsuspected and critical role in neural development and clusters of acetylcholine receptors were concentrated in the central region of skeletal muscles, thereby revealing patterning mechanisms that are autonomous to skeletal muscle. Expand
DNA topoisomerase IIβ and neural development
TLDR
DNA topoisomerase IIβ is shown to have an unsuspected and critical role in neural development and clusters of acetylcholine receptors were concentrated in the central region of skeletal muscles, thereby revealing patterning mechanisms that are autonomous to skeletal muscle. Expand
Src, Fyn, and Yes Are Not Required for Neuromuscular Synapse Formation But Are Necessary for Stabilization of Agrin-Induced Clusters of Acetylcholine Receptors
TLDR
Data show that the stabilization of agrin-induced AChR clusters requires Src and Fyn and suggest that the adaptor activities, rather than the kinase activities, of these kinases are essential for this stabilization. Expand
Recent progress towards understanding the synaptic ribbon
Neurons of the visual, auditory and vestibular systems that signal through graded changes in membrane potential rely upon synaptic ribbons for the exquisite control of neurotransmitter release.Expand