• Publications
  • Influence
Quantitative molecular assessment of chimerism across tissues in marmosets and tamarins
TLDR
The levels of chimerism in tissues of different origins coupled with other lines of evidence suggest that indeed only hematopoietic cell lineages are chimeric in callitrichids.
Differential Contribution of Dietary Fat and Monosaccharide to Metabolic Syndrome in the Common Marmoset (Callithrix jacchus)
TLDR
Feeding nutritionally modified diets to common marmosets recapitulates aspects of metabolic disease and represents a model that may prove instrumental to elucidating the contribution of nutrient excess to disease development.
Direct Intracranial Injection of AAVrh8 Encoding Monkey β-N-Acetylhexosaminidase Causes Neurotoxicity in the Primate Brain.
TLDR
Most monkeys receiving AAVrh8-cmHexα/β intracranial injection developed dyskinesias, ataxia, and loss of dexterity, with higher dose animals eventually becoming apathetic, and this study demonstrates the variations in safety profiles of AAV rh8-Hex α- and β-subunits among different species, despite encoding for self-proteins.
Brain creatine elevation and N‐acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of NeuroAIDS
TLDR
High creatine levels in a rapid progression macaque model of neuroAIDS may reflect enhanced high‐energy phosphate turnover in highly metabolizing activated astrocytes and microglia.
Colonization with nontuberculous mycobacteria is associated with positive tuberculin skin test reactions in the common marmoset (Callithrix jacchus).
TLDR
Colonization with NTM organisms represents a cause of suspect TST reactions in common marmosets and a multifocal lymphadenopathy and granulomatous lymphadenitis in 2 of 4 TST-positive marmoset examined.
CD8+ lymphocyte depletion without SIV infection does not produce metabolic changes or pathological abnormalities in the rhesus macaque brain
TLDR
The objective of this study is to confirm that CD8 depletion alone does not induce brain lesions in the absence of SIV infection.
Biphasic Malignant Testicular Sex Cord-Stromal Tumor in a Cotton-top Tamarin (Saguinus oedipus) with Review of the Literature
TLDR
A 20–year old male cotton-top tamarin (Saguinus oedipus) was presented with unilateral enlargement of an intrascrotal testicle and euthanized on discovery of a caudal abdominal mass that displaced organs, was highly infiltrative, and extended into the paravertebral musculature with lysis of vertebral bone.
710. Optimization of AAV Vector Design for Safe Expression of β-N-Acetylhexosaminidase in the Brain for Tay-Sachs Disease Gene Therapy
TLDR
Two new AAV vectors have been identified for safe overexpression of HexA in the primate brain, and these designs emerged and were tested in cynomolgus macaques infused bilaterally into the thalamus and cerebral lateral ventricle at the intermediate dose as in the first study.