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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products.
Wound healing properties of plant extracts that contain the naphthoquinone natural products alkannin (1) and shikonin (2) have been known for many centuries. More recently, the biological propertiesExpand
Total synthesis of taxol
TAXOL1–4, a substance originally isolated from the Pacific yew tree (Taxus brevifolia) more than two decades ago, has recently been approved for the clinical treatment of cancer patients. Hailed asExpand
Evaluation of naturally occurring curcuminoids and related compounds against mosquito larvae.
The three curcuminoid components commonly isolated from Curcuma longa, curcumin (1), demethoxycurcumin (2), and bis-demethoxycurcumin (3) were separated and isolated from a commercially availableExpand
Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens
Concentration-dependent mortality effects were observed for three pure synthetic natural products (alkannin, shikonin, and shikalkin) and three acetylated derivatives of shikonin against CulexExpand
Formal synthesis of Abyssomicin C
Abstract An alternative strategy towards Abyssomicin C ( 1 ) is described. The key ene-diene intermediate is synthesized via a Kishi type coupling of an E / Z mixture of triene-iodide 7 and aExpand
Interferon lambda1/IL‐29 and inorganic polyphosphate are novel regulators of neutrophil‐driven thromboinflammation
Neutrophils and neutrophil‐released meshwork structures termed neutrophil extracellular traps (NETs) are major mediators of thromboinflammation and emerging targets for therapy, yet the mechanismsExpand
Total synthesis of taxol.
Efficient Synthesis of Aminonaphthoquinones and Azidobenzohydroquinones: Mechanistic Considerations of the Reaction of Hydrazoic Acid with Quinones. An Overview.
Parameters useful to predict and control the reaction outcome of conjugate addition of hydrazoic acid to quinones have been studied, and the optimum conditions for the efficient synthesis ofExpand
Synthesis and Evaluation of Three Novel Scyphostatin Analogues as Neutral Sphingomyelinase Inhibitors
Low-molecular-weightinhibit ors of sphingomyelinases have attracted considerable attention as molecular tools for the investigation of the enzymatic mechanism of the various isoforms of these enzymesExpand
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