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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
TLDR
APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80. Expand
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
TLDR
A protective effect of the ε2 allele, in addition to the dose effect ofThe ε4 allele in sporadic AD, is demonstrated, which further support the direct involvement of APOE in the pathogenesis of AD. Expand
Vitamin D and prostate cancer: a prediagnostic study with stored sera.
TLDR
In men > or = 57 years of age, 1,25-D was an important predictor of risk for palpable and anaplastic tumors but not for tumors incidentally discovered during surgery to treat the symptoms of benign prostatic hyperplasia or well differentiated tumors. Expand
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy
TLDR
Comparison of frequency of neurologic symptoms for subjects with and without the E4 isoform (E4(+)and E4(–), respectively) in an HIV cohort shows that long-term survivors of HIV infection with E4 may be at high risk for AD; conversely, gene–viral interactions may speed AD pathogenesis. Expand
Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype
TLDR
The data point to the absence of an important function of apolipoprotein E-epsilon 3 or apoE2 in individuals who do not inherit these alleles as the genetically relevant metabolic factor, which has important implications for design of experiments directed toward understanding the relevant neuronal metabolism. Expand
The Biphasic Relationship between Regional Brain Senile Plaque and Neurofibrillary Tangle Distributions: Modification by Age, Sex, and APOE Polymorphism
TLDR
E Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men, and the extent of AD brain lesions (NFT and SP) was compared for men and women at each age, in a large sample of routine autopsy cases. Expand
Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease
TLDR
It is concluded that the progression of AD is not strongly related to ε4 gene dose, that the higher prevalence of AD in women may involve the longer survival of affected women, and that AD and death are competing risks involving APOE that change over time. Expand
The role of APOE polymorphisms in late-onset dementias
TLDR
The association of both types of AD-related changes with the occurrence of ε4 suggests that the APOE polymorphism causally contributes to the pathogenesis of AD. Expand
Density profiles of Alzheimer disease regional brain pathology for the Huddinge brain bank: pattern recognition emulates and expands upon Braak staging
TLDR
Density profiles of Alzheimer's disease regional brain pathology were constructed for 249 subjects in the Huddinge Brain Bank using a pattern recognition technique called GoM and showed apparent rapid transition of DP to NP in the cortex during clinical progression. Expand
Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease.
TLDR
The isoform-specific metabolism of apoE resulting in a faster rate of disease expression can now be studied with the expectation that genetically relevant processes are being investigated and there is now an opportunity to develop theories directed at the genetically relevant APOE metabolism that can significantly delay disease expression. Expand
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