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Effect of in vitro culture of human embryos on birthweight of newborns.
BACKGROUND In animal models, in vitro culture of preimplantation embryos has been shown to be a risk factor for abnormal fetal outcome, including high and low birthweight. In the human, mean… Expand
Optimal preparation of preimplantation embryo interphase nuclei for analysis by fluorescence in-situ hybridization.
A new method was developed to prepare and isolate interphase nuclei from murine preimplantation embryos for analysis by fluorescence in-situ hybridization. Embryos were washed with phosphate-buffered… Expand
Identification of the sex of human preimplantation embryos in two hours using an improved spreading method and fluorescent in-situ hybridization (FISH) using directly labelled probes.
Dual fluorescent in-situ hybridization (FISH) using X and Y chromosome specific probes has been used to identify the sex of human embryos for preimplantation diagnosis of X-linked disease. With a… Expand
Anaphase lagging mainly explains chromosomal mosaicism in human preimplantation embryos.
BACKGROUND Cleavage stage embryos as well as postimplantation embryos have been studied extensively over the years. However, our knowledge with respect to the chromosomal constitution of human… Expand
What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium Steering Committee.
Since 2004, there have been 11 randomized controlled trials (RCTs) mainly for advanced maternal age (AMA), which have shown no benefit of performing preimplantation genetic screening (PGS). Ten of… Expand
ESHRE PGD Consortium data collection X: cycles from January to December 2007 with pregnancy follow-up to October 2008.
The 10th report of the European Society of Human Reproduction and Embryology (ESHRE) PGD Consortium is presented, documenting cycles collected for the calendar year 2007 and follow-up of the… Expand
Mosaicism of autosomes and sex chromosomes in morphologically normal, monospermic preimplantation human embryos
- J. Harper, E. Coonen, A. Handyside, R. Winston, A. Hopman, J. Delhanty
- Biology, Medicine
- Prenatal diagnosis
- 1 January 1995
We have previously detected chromosome abnormalities in human embryos whilst identifying the sex for preimplantation diagnosis of X‐linked disease. In this study we assess the incidence of these… Expand
Effect of oxygen concentration on human in-vitro fertilization and embryo culture.
- J. Dumoulin, C. J. Meijers, M. Bras, E. Coonen, J. Geraedts, J. Evers
- Biology, Medicine
- Human reproduction
- 1 February 1999
In this prospective randomized study on 1380 consecutive in-vitro fertilization (IVF) treatments, the results were compared of culture of human oocytes and embryos for the first 2 or 3 days of… Expand
Embryo development and chromosomal anomalies after ICSI: effect of the injection procedure.
Intracytoplasmic sperm injection (ICSI) is a delicate procedure requiring considerable skills of the person performing it. Theoretically, the injection procedure could damage cytoplasmic structures… Expand
ESHRE PGD Consortium data collection XII: cycles from January to December 2009 with pregnancy follow-up to October 2010.
STUDY QUESTION How do data in the 12th annual data collection (Data XII) of the European Society of Human Reproduction and Embryology Preimplantation Genetic Diagnosis (PGD) Consortium compare with… Expand