• Publications
  • Influence
Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana.
TLDR
This study provides the first complete pharmacokinetic profile of the absorption of THC and appearance of metabolites during marijuana smoking, which has implications for understanding the mechanisms underlying the performance-impairing effects of marijuana, as well as for aiding forensic interpretation of cannabinoid blood levels. Expand
Clinical pharmacology of buprenorphine: Ceiling effects at high doses
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
Pharmacokinetics and pharmacodynamics of cocaine.
  • E. Cone
  • Medicine
  • Journal of analytical toxicology
  • 1 October 1995
TLDR
It is demonstrated that cocaine administration by the smoked route produced substantially higher behavioral responses than an equivalent dose of cocaine administered by the intravenous route, and this finding suggests that smoked cocaine (crack) has a higher abuse liability and greater dependence-producing properties than equivalent doses of cocaineadministered byThe intravenous or intranasal route. Expand
Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana.
TLDR
It was concluded that oral fluid testing for THC offers specific advantages over other means of marijuana testing when used in safety-sensitive testing programs. Expand
Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study.
TLDR
The results indicate that unique structural requirements exist for each transporter site, but that cocaine binding at norepinephrine and dopamine transporters can be described by more similar structure-activity relationships than those found for the serotonin transporter. Expand
Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.
TLDR
A new, highly selective ligand for the sigma receptor is described and distinctly different structural requirements for binding to sigma and PCP receptors are confirmed and provide a new structural consideration for synthesizing sigma-selective compounds. Expand
Mechanisms of drug incorporation into hair.
  • E. Cone
  • Chemistry, Medicine
  • Therapeutic drug monitoring
  • 1 August 1996
TLDR
Hair testing for drugs of abuse is a developing technology that offers the possibility of longer detection times than is commonly obtained with urine or blood analysis and recent in vitro studies suggest that the color of hair or melanin content may be the major determinant of cocaine binding and may result in color or ethnic bias in hair testing. Expand
Differentiating new marijuana use from residual drug excretion in occasional marijuana users.
TLDR
Data indicated that selection of a specimen ratio to evaluate sequential creatinine normalized urine drug concentrations can improve the ability to distinguish residual excretion from new marijuana usage. Expand
Arterial and venous cocaine plasma concentrations in humans: relationship to route of administration, cardiovascular effects and subjective effects.
TLDR
Even though arterial and venous cocaine concentrations were lower after smoked cocaine, compared with i.v. cocaine, the magnitudes of cardiovascular and subjective effects were similar, suggesting that smoked cocaine may produce a greater effect at similar concentrations. Expand
Relationship of Delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis.
  • M. Huestis, E. Cone
  • Chemistry, Medicine
  • Journal of analytical toxicology
  • 1 September 2004
TLDR
It is concluded that a positive oral fluid test provides credible evidence of active cannabis use and the similarity in oral fluid and plasma THC concentrations following the dissipation of the initial "contamination" indicates the likelihood of a physiological link between these specimens. Expand
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