• Publications
  • Influence
Blood cannabinoids. I. Absorption of THC and formation of 11-OH-THC and THCCOOH during and after smoking marijuana.
delta 9-Tetrahydrocannabinol (THC), the primary psychoactive constituent of marijuana, is rapidly transferred from lungs to blood during smoking. Oxidative metabolism of THC yields the activeExpand
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Clinical pharmacology of buprenorphine: Ceiling effects at high doses
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide range of doses in comparison to methadone.
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Pharmacokinetics and pharmacodynamics of cocaine.
  • E. Cone
  • Chemistry, Medicine
  • Journal of analytical toxicology
  • 1 October 1995
A dramatic shift has occurred over the last decade in the route of cocaine administration by drug abusers in the United States. The favored route has changed from intranasal and intravenous use toExpand
  • 179
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Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study.
Structure-activity relationships for cocaine and analog binding at the dopamine, norepinephrine and serotonin transporters were determined. Cocaine inhibition of ligand binding to each of these sitesExpand
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Detection of marijuana use by oral fluid and urine analysis following single-dose administration of smoked and oral marijuana.
We compared oral fluid testing to urine testing in subjects who were administered single doses of marijuana by smoked and oral routes. Oral fluid specimens were collected with the Intercept DOA OralExpand
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Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.
A series of compounds derived from phencyclidine (PCP) was examined in the sigma receptor and PCP receptor binding assays. The derivatives included compounds containing methylene, ethylene orExpand
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Mechanisms of drug incorporation into hair.
  • E. Cone
  • Chemistry, Medicine
  • Therapeutic drug monitoring
  • 1 August 1996
Hair testing for drugs of abuse is a developing technology that offers the possibility of longer detection times than is commonly obtained with urine or blood analysis. There are many uncertaintiesExpand
  • 172
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Differentiating new marijuana use from residual drug excretion in occasional marijuana users.
Increases in urine drug concentration that result from changes in urinary output may be mistakenly interpreted as new drug use rather than carryover from previous drug exposure. Normalization of drugExpand
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Relationship of Delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis.
  • M. Huestis, E. Cone
  • Medicine, Chemistry
  • Journal of analytical toxicology
  • 1 September 2004
Understanding the relationship of Delta(9)-tetrahydrocannabinol (THC) concentrations in oral fluid and plasma is important in interpretation of oral fluid test results. Current evidence suggests thatExpand
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Saliva testing for drugs of abuse.
  • E. Cone
  • Medicine, Biology
  • Annals of the New York Academy of Sciences
  • 1 September 1993
Saliva testing for drugs of abuse can provide both qualitative and quantitative information on the drug status of an individual undergoing testing. Self-administration by the oral, intranasal, andExpand
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