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Biological properties of extracellular vesicles and their physiological functions
A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Novel molecular profiles of endometrial cancer—new light through old windows
Endometrial carcinoma: molecular alterations involved in tumor development and progression
In this review, the genetic changes of endometrial carcinogenesis are discussed in the light of the morphological features of the tumors and their precursors.
The EMT signaling pathways in endometrial carcinoma
- E. Colás, N. Pedrola, J. Reventós
- Medicine, BiologyClinical and Translational Oncology
- 22 August 2012
The most common hallmarks of EMT have been found in EC, either at the level of E-cadherin loss or at the induction of its repressors, as well as other molecular alterations consistent with the mesenchymal phenotype-like L1CAM and BMI-1 up-regulation.
Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer
The CTC-phenotype found in endometrial CTC was recapitulated by over-expressing ETV5 in the EC cell line Hec1A and demonstrated an advantage in the promotion of metastasis in an in vivo mouse model of CTC dissemination and homing.
L1CAM expression in endometrial carcinomas: an ENITEC collaboration study
The expression of L1CAM is a strong predictor of poor outcome in EECs, but not NEECs; it is strongly associated with non-endometrioid histology and distant spread, and could improve the postoperative selection of high-risk endometrial carcinomas.
The Present and Future of Prostate Cancer Urine Biomarkers
The most significant urine biomarkers described in recent years are reviewed, as well as some future prospects in that field.
Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion
NID1 and NUPR1 are novel targets of ETV5 and are actively cooperating with ETV 5 at the invasion front of the tumor in the acquisition of an invasive phenotype to jointly drive endometrial cancer invasion.
Molecular bases of endometrial cancer: New roles for new actors in the diagnosis and the therapy of the disease
Enabling Metabolomics Based Biomarker Discovery Studies Using Molecular Phenotyping of Exosome-Like Vesicles
Evidence is presented that indeed ELVs carry a rich metabolome that could not only augment the discovery of low abundance biomarkers but may also help explain the molecular basis of disease progression.