• Publications
  • Influence
Host microbiota constantly control maturation and function of microglia in the CNS
As the tissue macrophages of the CNS, microglia are critically involved in diseases of the CNS. However, it remains unknown what controls their maturation and activation under homeostatic conditions.Expand
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Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.
Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that symbiotic Fusobacterium spp. are associated with human colorectal carcinoma, but whether thisExpand
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CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function
Summary Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancerExpand
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Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma1
  • Y. Kim, S. Oh, +13 authors Z. Zhu
  • Biology, Medicine
  • The Journal of Immunology
  • 15 April 2007
Allergic asthma is characterized by airway inflammation initiated by adaptive immune responses to aeroallergens. Recent data suggest that severe asthma may be a different form of asthma rather thanExpand
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TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-κB*
Background: ECSIT as a multifunctional protein is involved in TLR signals. However, its regulatory function is not fully characterized. Results: ECSIT forms a high molecular endogenous complexExpand
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Anti‐inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation
Oxidative stress is implicated in the pathogenesis of allergic asthma and remains an attractive target for the prevention of the disease. Herein, we investigated the anti‐inflammatory effects ofExpand
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The role of high‐mobility group box‐1 (HMGB1) in the pathogenesis of asthma
High‐mobility group box 1 protein (HMGB1) belonging to endogenous danger signals prolongs eosinophil survival and acts as a chemoattractant.
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AMP-activated protein kinase-α1 as an activating kinase of TGF-β-activated kinase 1 has a key role in inflammatory signals
Although previous studies have proposed plausible mechanisms of the activation of transforming growth factor-β-activated kinase 1 (TAK1) in inflammatory signals, including Toll-like receptors (TLRs),Expand
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TH2 and TH1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA.
  • S. Jeon, S. Oh, +11 authors Y. Kim
  • Biology, Medicine
  • The Journal of allergy and clinical immunology
  • 1 October 2007
BACKGROUND Although respiratory viral infections in early childhood can enhance the development of airway allergen sensitization, the exact mechanisms of the effects of viral infections on theExpand
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Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity.
Group 3 innate lymphoid cells (ILC3s) sense environmental signals that are critical for gut homeostasis and host defense. However, the metabolite-sensing G-protein-coupled receptors that regulateExpand
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